Ishibe T, Kubo N, Kumazawa H, Yamashita T, Kamazawa T
Ann Otol Rhinol Laryngol. 1985 Mar-Apr;94(2 Pt 1):186-90. doi: 10.1177/000348948509400218.
An increased number (density) or sensitivity (affinity) of histamine H1 receptors could cause an increase of allergic symptoms. Using the specific H1 receptor blocker 3H-mepyramine, we have demonstrated for the first time an H1 receptor number (Bmax) and a binding affinity (Kd) in guinea pig and human nasal mucosa. H1 antihistamines inhibited that 3H-mepyramine binding sites represent H1 receptors in nasal mucosa. Bmax and Kd values were not significantly different among the nonallergic sinusitis, vasomotor rhinitis, or the nasal allergy group, suggesting that H1 receptors do not change quantitatively and qualitatively in allergic nasal mucosa. There was no significant correlation between H1 receptor number and clinical data (IgE, peripheral eosinophils, RAST). These data suggest that H1 receptor number and affinity are not main etiological and pathophysiological factors in nasal allergy.
组胺H1受体数量（密度）增加或敏感性（亲和力）增强可导致过敏症状加重。我们使用特异性H1受体阻滞剂3H-美吡拉敏，首次在豚鼠和人鼻黏膜中证实了H1受体数量（最大结合容量）和结合亲和力（解离常数）。H1抗组胺药抑制了3H-美吡拉敏结合位点代表鼻黏膜中的H1受体。在非过敏性鼻窦炎、血管运动性鼻炎或鼻过敏组中，最大结合容量和解离常数的值无显著差异，这表明过敏性鼻黏膜中的H1受体在数量和质量上均无变化。H1受体数量与临床数据（免疫球蛋白E、外周嗜酸性粒细胞、放射性变应原吸附试验）之间无显著相关性。这些数据表明，H1受体数量和亲和力并非鼻过敏的主要病因和病理生理因素。
