Fang Wen-Tao, Lv Yong-Feng, Ren Fu-Cai, Zhang Hong, Xie Dong-Mei, Zhang Xiao-Bo, Fang Cheng-Wu, Liu Shou-Jin, Luo Han
College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China.
College of Science, Westlake University, Hangzhou 310024, China.
Molecules. 2025 Feb 6;30(3):750. doi: 10.3390/molecules30030750.
To discover novel, potent anti-inflammatory diterpenoids, a series of hybrids of 7-oxodehydroabietic acid bearing a 1,2,3-triazole moiety was designed and synthesized. The target compounds were characterized by means of H NMR, C NMR, and ESI-HRMS. All the compounds were evaluated for their anti-inflammatory activity towards BV2 cell lines using L-NMMA (IC = 42.36 ± 2.47 µM) as a positive control. Most showed good anti-inflammatory activities, especially compounds (IC = 8.40 ± 0.98 µM), (IC = 10.74 ± 2.67 µM), (IC = 10.96 ± 1.85 µM), and (IC = 9.76 ± 1.27 µM), which exhibited potent anti-inflammatory effects on BV2 cell lines.
为发现新型、高效的抗炎二萜类化合物，设计并合成了一系列带有1,2,3-三唑部分的7-氧代脱氢枞酸杂化物。通过1H NMR、13C NMR和ESI-HRMS对目标化合物进行了表征。以L-NMMA（IC = 42.36 ± 2.47 µM）作为阳性对照，评估了所有化合物对BV2细胞系的抗炎活性。大多数化合物表现出良好的抗炎活性，尤其是化合物（IC = 8.40 ± 0.98 µM）、（IC = 10.74 ± 2.67 µM）、（IC = 10.96 ± 1.85 µM）和（IC = 9.76 ± 1.27 µM），它们对BV2细胞系表现出强效抗炎作用。
