Mastacchi R, Bartolini G, Orlandi M, Chiricolo M, Guerrini F, Franceschi C, Tomasi V
Anticancer Res. 1985 Mar-Apr;5(2):167-70.
This paper reviews the evidence pointing to a role of prostaglandins and cyclic AMP in the regulation of surveillance processes against transformed cells carried out by activated monocytes macrophages and natural killer (NK) cells. Specific topics of discussion include: (a) the regulation of monocyte/macrophage system and NK cells by prostaglandins and cyclic AMP; and (b) the possible immunomodulatory role of thromboxanes generated by activated monocytes and macrophages. Also the role of cyclic AMP dependent and independent protein kinases as well as their link with oncogenes is briefly reviewed.
本文综述了有关前列腺素和环磷酸腺苷（cAMP）在调节活化单核细胞、巨噬细胞和自然杀伤（NK）细胞针对转化细胞的监测过程中所起作用的证据。讨论的具体主题包括：（a）前列腺素和环磷酸腺苷对单核细胞/巨噬细胞系统及NK细胞的调节；（b）活化单核细胞和巨噬细胞产生的血栓素可能具有的免疫调节作用。此外，还简要综述了环磷酸腺苷依赖性和非依赖性蛋白激酶的作用及其与癌基因的联系。
