[西咪替丁对低血糖诱导的生长激素分泌的影响]
[Influence of cimetidine on hypoglycemia-induced GH secretion].
作者信息
Campanella N, Morosini P P, Rinaldi L, Testa I, De Martinis C
出版信息
Boll Soc Ital Biol Sper. 1979 Jan 15;55(1):7-9.
PMID:399438
Abstract
Dopaminergic drugs inhibit prolactin and stimulate GH secretion. On the contrary antidopaminergic drugs stimulate prolactin and decrease hypoglycemia-induced GH secretion. According to the hypothesis that Cimetidine, an H2-receptor antagonist, decreases hypothalamic dopamine secretion, it was evaluated GH response to hypoglycemia after this drug. It was demonstrated that Cimetidine decreases hypoglycemia-induced GH secretion.
摘要
多巴胺能药物抑制催乳素并刺激生长激素分泌。相反，抗多巴胺能药物刺激催乳素分泌并减少低血糖诱导的生长激素分泌。根据H2受体拮抗剂西咪替丁会降低下丘脑多巴胺分泌这一假说，对用药后生长激素对低血糖的反应进行了评估。结果表明，西咪替丁可减少低血糖诱导的生长激素分泌。
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