Song Peiji, Li Kun, Xu Xiaodie, Zhang Guifeng, Wang Zengkun, Sun Linbing, Zhao Zekai, Li Ting, Wang Ximing, Xia Zhangyong
First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Department of Radiology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Front Pharmacol. 2025 Jan 29;16:1538916. doi: 10.3389/fphar.2025.1538916. eCollection 2025.
This study aims to investigate the protective effects of against renal injury induced by low-dose contrast medium (CM) in coronary computed tomography angiography (CCTA) imaging, and to evaluate its efficacy using functional magnetic resonance imaging (fMRI).
Twenty Beagle dogs with induced renal insufficiency were enrolled in the study and randomly assigned to one of four groups (n = 5 per group). Group A received for 1 week prior to undergoing heart rate-dependent personalized CM CCTA scanning; Group B received for 1 week followed by conventional dose CM CCTA scanning; Group C did not receive but underwent HR-dependent CM CCTA scanning; and Group D did not receive but underwent conventional dose CM CCTA scanning. Renal function was assessed using MRI before and after the intervention, with IVIM (Intravoxel Incoherent Motion) and BOLD (Blood Oxygen Level Dependent) imaging of the kidneys. Key parameters, including the pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), and R2*values, were quantified. Laboratory renal function markers were measured multiple times before and after the intervention, and their correlation with fMRI parameters was analyzed.
CCTA imaging revealed that the CT values of the major coronary artery branches in all groups met the international diagnostic criteria for coronary arteries. No statistically significant differences in image quality were observed among the four groups (P > 0.05). In Groups A and D, significant changes were observed in renal function parameters, as well as in D, D*, f, and R2* values, both pre- and post-CCTA (P < 0.05). However, Groups B and C exhibited no significant changes pre- and post-CCTA (P > 0.05). A significant correlation was found between MRI parameters and laboratory renal function markers, with excellent inter- and intra-observer reproducibility, and high repeatability in the measurements.
HR-dependent personalized CM CCTA imaging did not compromise image quality. Administration of demonstrated a potential protective effect on renal function. The combination of IVIM and BOLD functional MRI offers a reliable, non-invasive approach to assess the protective effects of on renal injury induced by low-dose CCTA in Beagle dogs.
本研究旨在探讨[具体物质名称未给出]对冠状动脉计算机断层扫描血管造影（CCTA）成像中低剂量造影剂（CM）所致肾损伤的保护作用，并使用功能磁共振成像（fMRI）评估其疗效。
将20只诱导性肾功能不全的比格犬纳入研究，并随机分为四组（每组n = 5）。A组在进行心率依赖性个性化CM CCTA扫描前1周接受[具体物质名称未给出]；B组接受[具体物质名称未给出]1周，随后进行常规剂量CM CCTA扫描；C组未接受[具体物质名称未给出]，但进行了心率依赖性CM CCTA扫描；D组未接受[具体物质名称未给出]，但进行了常规剂量CM CCTA扫描。在干预前后使用MRI评估肾功能，并对肾脏进行体素内不相干运动（IVIM）和血氧水平依赖（BOLD）成像。对包括纯扩散系数（D）、伪扩散系数（D*）、灌注分数（f）和R2*值在内的关键参数进行量化。在干预前后多次测量实验室肾功能指标，并分析其与fMRI参数的相关性。
CCTA成像显示，所有组主要冠状动脉分支的CT值均符合冠状动脉国际诊断标准。四组之间图像质量无统计学显著差异（P > 0.05）。在A组和D组中，CCTA前后肾功能参数以及D、D*、f和R2*值均有显著变化（P < 0.05）。然而，B组和C组在CCTA前后无显著变化（P > 0.05）。发现MRI参数与实验室肾功能指标之间存在显著相关性，观察者间和观察者内的再现性良好，测量的重复性高。
心率依赖性个性化CM CCTA成像不影响图像质量。给予[具体物质名称未给出]对肾功能显示出潜在的保护作用。IVIM和BOLD功能MRI的联合应用为评估[具体物质名称未给出]对低剂量CCTA诱导的比格犬肾损伤的保护作用提供了一种可靠的非侵入性方法。
