[Bone formation after graded distraction in patients with open fractures of the long tubular bones complicated by purulent infection].

Osteogenesis under the above conditions is studied on the material of biopsies from 22 men with the open fractures of long bones complicated with a purulent infection. The increasing space between the edges of the fractured bone is filled with an osteoid tissue and subsequently a normal bone tissue is formed. The cells with a high proliferative activity (an intense DNA synthesis) are localised exclusively or predominantly in the wall of the capillary type vessels or in their vicinity. This indicates a close link between angiogenesis and osteogenesis. It is possible that the undifferentiated precursor cell which is the main source of the formation of all components of a new bone is localised in the wall of small vessels as a pericyte or adventitial cell. The method of graded distractional osteosynthesis in combination with the use of a controlled abacterial medium gives a possibility to replace without a free bone transplant big bone defects in open fractures complicated with a purulent infection.