Permiakov N K, Butenin A M
Arkh Patol. 1985;47(2):5-16.
On the material of 200 necropsies and 230 surgically amputated lower extremities in patients with an acute obstruction of the main arteries as well as the study of the limb muscles in the appropriate experimental models, the principal rules and the pathogenesis of the muscle damage in the ischemic disease of the lower extremities (IDLE) are described. Four clinico-anatomical variants of the acute IDLE are distinguished: (1) diffuse degenerative-necrotic muscle damage; (2) large-focal necrosis; (3) massive isolated necrosis of single muscles; (4) limb gangrene. Grave general and local somatic background in a patient, causes of death and role of the IDLE in thanatogenesis are characterized.
基于200例尸检材料以及230例因主动脉急性阻塞而接受手术截肢的下肢患者，并通过对相应实验模型中的肢体肌肉进行研究，阐述了下肢缺血性疾病（IDLE）中肌肉损伤的主要规律及发病机制。区分出急性IDLE的四种临床解剖学类型：（1）弥漫性变性坏死性肌肉损伤；（2）大片局灶性坏死；（3）单个肌肉的大块孤立性坏死；（4）肢体坏疽。对患者严重的全身和局部躯体背景、死亡原因以及IDLE在死因形成中的作用进行了描述。
