Mihalakakos Evan A, Ssempijja Victor, Ribeiro Ruy M, Molina-Paris Carmen, Katushabe Gerald, Nalwadda Josephine, Omooja Jonah, Byarugaba Denis K, Rosenke Kyle, Reynolds Steven J, Grabowski Mary K, Galiwango Ronald M, Ssekubugu Robert, Feldmann Heinz, Hawman David W
Laboratory of Virology, Rocky Mountain Laboratories, NIAID/NIH, Hamilton, MT, USA.
Laboratory of Immunoregulation, NIAID/NIH, Bethesda, MD, USA.
Emerg Microbes Infect. 2025 Dec;14(1):2465315. doi: 10.1080/22221751.2025.2465315. Epub 2025 Mar 3.
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease endemic to many regions of Africa, the Middle East, Southeast Asia and the Balkans. Caused by the CCHF virus (CCHFV), CCHF has been a recognized cause of illness in Uganda since the 1950s and recently, more intensive surveillance suggests CCHFV is widely endemic within the country. Most surveillance has been focused on the Ugandan cattle corridor due to the risk of CCHFV exposure associated with livestock practices. Here we evaluated the seroprevalence of CCHFV in several Southern Ugandan communities outside the cattle corridor combined with longitudinal sample sets to measure the immune response to CCHFV for up to a decade. Interestingly, across three community types, agrarian, trading and fishing, we detected CCHFV seroprevalence in all three but found the highest seroprevalence in fishing communities. We also measured consistent CCHFV-specific antibody responses for up to a decade. Our findings support the conclusion that CCHFV is widely endemic in Uganda and highlight that additional communities may be at risk for CCHFV exposure.
克里米亚-刚果出血热（CCHF）是一种由蜱传播的疾病，在非洲、中东、东南亚和巴尔干半岛的许多地区流行。由克里米亚-刚果出血热病毒（CCHFV）引起，自20世纪50年代以来，CCHF在乌干达一直被认为是一种致病原因，最近，更密集的监测表明CCHFV在该国广泛流行。由于与畜牧业相关的CCHFV暴露风险，大多数监测都集中在乌干达的牛走廊。在这里，我们评估了牛走廊以外的几个乌干达南部社区中CCHFV的血清流行率，并结合纵向样本集来测量长达十年对CCHFV的免疫反应。有趣的是，在农业、贸易和渔业这三种社区类型中，我们在所有三种社区中都检测到了CCHFV血清流行率，但发现渔业社区的血清流行率最高。我们还测量了长达十年的一致的CCHFV特异性抗体反应。我们的研究结果支持CCHFV在乌干达广泛流行的结论，并强调其他社区可能有CCHFV暴露的风险。
