Willis A L, Nagel B, Churchill V, Whyte M A, Smith D L, Mahmud I, Puppione D L
Arteriosclerosis. 1985 May-Jun;5(3):250-5. doi: 10.1161/01.atv.5.3.250.
Dutch-belted rabbits fed a 2% cholesterol diet for 8 weeks developed atherosclerotic lesions that covered 37.2% +/- 3.5% of the aortic luminal surface. In samples of aortic arch, accumulation of cholesterol and triglyceride was also observed. Oral administration of nicardipine or nifedipine at dosages of 40 mg/kg twice daily for 8 weeks reduced plaque area by 49.2% and 58.7%, respectively. Nicardipine and nifedipine reduced cholesterol accumulation in the aortic arch by 74.5% and 69%, respectively. Triglyceride accumulation was totally abolished. Neither drug significantly altered cholesterol concentration of plasma low density lipoprotein or high density lipoprotein, although nicardipine produced a 42% reduction in cholesterol concentration of the d less than 1.006 g/ml fraction. The above results suggest potential therapeutic utility of nicardipine in atherosclerosis.
给荷兰带兔喂食含2%胆固醇的饲料8周后，其动脉粥样硬化病变覆盖了主动脉管腔表面的37.2%±3.5%。在主动脉弓样本中，也观察到了胆固醇和甘油三酯的积累。每日两次口服剂量为40mg/kg的尼卡地平或硝苯地平，持续8周，斑块面积分别减少了49.2%和58.7%。尼卡地平和硝苯地平分别使主动脉弓中的胆固醇积累减少了74.5%和69%。甘油三酯的积累完全消除。两种药物均未显著改变血浆低密度脂蛋白或高密度脂蛋白的胆固醇浓度，尽管尼卡地平使密度小于1.006g/ml部分的胆固醇浓度降低了42%。上述结果表明尼卡地平在动脉粥样硬化治疗中具有潜在的应用价值。
