Attias J, Pratt H
Audiology. 1985;24(2):149-56. doi: 10.3109/00206098509081548.
Correlations between changes in cochlear microphonics (CM) and auditory brainstem-evoked potentials (ABEP) resulting from transitory-threshold-shift (TTS)-inducing noise, in normally hearing subjects, and the eventual permanent threshold shift (PTS) which the same subjects developed after 9-14 months of well-quantified occupational noise were evaluated. In addition, the predictive value of pigmentation, as an indicator of eventual PTS, was assessed. Eleven CM and ABEP indices which showed significant correlation with the eventual hearing loss were identified. Eight of these indices reflect the effect of increased stimulus rate and experimental TTS-inducing noise. These results show that the difference in ABEP latencies as a result of increased stimulus rate is smaller in persons with large eventual PTS (high susceptibility to noise-induced hearing loss). The effect is larger in persons that eventually developed a small PTS (low susceptibility). Pigmentation, as reflected by iris and skin color, was found to have a negative correlation with susceptibility to noise, i.e. the more pigment the less PTS developed. The above indices may be useful to determine personal susceptibility to noise in normally hearing subjects.
对听力正常的受试者，评估了由暂时性阈移（TTS）诱导噪声引起的耳蜗微音电位（CM）变化与听性脑干诱发电位（ABEP）变化之间的相关性，以及这些受试者在9至14个月充分量化的职业噪声暴露后最终出现的永久性阈移（PTS）。此外，评估了色素沉着作为最终PTS指标的预测价值。确定了11个与最终听力损失显著相关的CM和ABEP指标。其中8个指标反映了刺激率增加和实验性TTS诱导噪声的影响。这些结果表明，最终PTS较大（对噪声性听力损失易感性高）的人，因刺激率增加导致的ABEP潜伏期差异较小。最终PTS较小（易感性低）的人，这种影响较大。虹膜和皮肤颜色所反映的色素沉着与噪声易感性呈负相关，即色素越多，PTS发展越少。上述指标可能有助于确定听力正常的受试者对噪声的个人易感性。
