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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study.与肝线粒体外膜相关的电子传递系统。一项生化与形态学研究。
J Cell Biol. 1967 Feb;32(2):415-38. doi: 10.1083/jcb.32.2.415.
3
Effect of sodium and potassium on ATP-dependent Ca2+ uptake in rat parotid microsomes.钠和钾对大鼠腮腺微粒体中ATP依赖的钙离子摄取的影响。
FEBS Lett. 1982 Jan 11;137(1):63-6. doi: 10.1016/0014-5793(82)80315-3.
4
Parotid microsomal Ca2+ transport. Subcellular localization and characterization.腮腺微粒体钙转运。亚细胞定位与特性
Biochem J. 1982 Dec 15;208(3):789-94. doi: 10.1042/bj2080789.
5
Ca++-transport across basal-lateral plasma membranes from rat small intestinal epithelial cells.钙离子从大鼠小肠上皮细胞的基底外侧质膜的转运。
J Membr Biol. 1982;65(1-2):55-62. doi: 10.1007/BF01870469.
6
Kinetic properties of the ATP-dependent Ca2+ pump and the Na+/Ca2+ exchange system in basolateral membranes from rat kidney cortex.大鼠肾皮质基底外侧膜中ATP依赖的Ca2+泵和Na+/Ca2+交换系统的动力学特性。
J Membr Biol. 1984;79(1):19-31. doi: 10.1007/BF01868523.
7
Sodium/calcium exchange in smooth-muscle microsomal fractions.平滑肌微粒体组分中的钠/钙交换
Biochem J. 1984 Mar 1;218(2):421-7. doi: 10.1042/bj2180421.
8
Na+-Ca2+ exchange activity in rabbit lymphocyte plasma membranes.兔淋巴细胞质膜中的钠钙交换活性。
Biochim Biophys Acta. 1983 Oct 12;734(2):342-6. doi: 10.1016/0005-2736(83)90133-5.
9
Kinetic properties of Na+/Ca2+ exchange in basolateral plasma membranes of rat small intestine.大鼠小肠基底外侧质膜中Na+/Ca2+交换的动力学特性。
Biochim Biophys Acta. 1983 Apr 21;730(1):85-94. doi: 10.1016/0005-2736(83)90320-6.
10
Na+-dependent, alpha-adrenergic mobilization of intracellular (mitochondrial) Ca2+ in brown adipocytes.棕色脂肪细胞中钠离子依赖的α-肾上腺素能介导的细胞内（线粒体）钙离子动员
Eur J Biochem. 1984 May 15;141(1):187-93. doi: 10.1111/j.1432-1033.1984.tb08173.x.

大鼠腮腺富含基底外侧质膜囊泡中的钙转运机制。

Calcium transport mechanisms in basolateral plasma membrane-enriched vesicles from rat parotid gland.

作者信息

Takuma T, Kuyatt B L, Baum B J

出版信息

Biochem J. 1985 Apr 1;227(1):239-45. doi: 10.1042/bj2270239.

DOI:10.1042/bj2270239
PMID:3994684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1144832/
Abstract

Ca2+ transport was studied by using basolateral plasma membrane vesicles from rat parotid gland prepared by a Percoll gradient centrifugation method. In these membrane vesicles, there were two Ca2+ transport systems; Na+/Ca2+ exchange and ATP-dependent Ca2+ transport. An outwardly directed Na+ gradient increased Ca2+ uptake. Ca2+ efflux from Ca2+-preloaded vesicles was stimulated by an inwardly directed Na+ gradient. However, Na+/Ca2+ exchange did not show any 'uphill' transport of Ca2+ against its own gradient. ATP-dependent Ca2+ transport exhibited 'uphill' transport. An inwardly directed Na+ gradient also decreased Ca2+ accumulation by ATP-dependent Ca2+ uptake. The inhibition of Ca2+ accumulation was proportional to the external Na+ level. Na+/Ca2+ exchange was inhibited by monensin, tetracaine and chlorpromazine, whereas ATP-dependent Ca2+ transport was inhibited by orthovanadate, tetracaine and chlorpromazine. Oligomycin had no effect on either system. These results suggest that in the parotid gland cellular free Ca2+ is extruded mainly by an ATP-dependent Ca2+ transport system, and Na+/Ca2+ exchange may modify the efficacy of that system.

摘要

采用通过Percoll梯度离心法制备的大鼠腮腺基底外侧质膜囊泡研究Ca2+转运。在这些膜囊泡中，存在两种Ca2+转运系统；Na+/Ca2+交换和ATP依赖的Ca2+转运。外向的Na+梯度增加Ca2+摄取。Ca2+预加载囊泡中的Ca2+外流受内向的Na+梯度刺激。然而，Na+/Ca2+交换未显示出任何逆自身梯度的Ca2+“上坡”转运。ATP依赖的Ca2+转运表现出“上坡”转运。内向的Na+梯度也通过ATP依赖的Ca2+摄取减少Ca2+积累。Ca2+积累的抑制与细胞外Na+水平成比例。Na+/Ca2+交换受莫能菌素、丁卡因和氯丙嗪抑制，而ATP依赖的Ca2+转运受原钒酸盐、丁卡因和氯丙嗪抑制。寡霉素对这两种系统均无影响。这些结果表明，在腮腺中，细胞内游离Ca2+主要通过ATP依赖的Ca2+转运系统排出，并且Na+/Ca2+交换可能会改变该系统的功效。