Aw T C, Kiechle F L
Am J Emerg Med. 1985 May;3(3):236-9. doi: 10.1016/0735-6757(85)90096-8.
Pseudohyponatremia should be distinguished from true hyponatremia lest injudicious therapy be instituted. Pseudohyponatremia is caused by a displacement of serum water by elevated concentrations of serum lipids or proteins. Only two (flame photometry and indirect potentiometry) of the three current methods available for measuring serum sodium involve sample dilution and may consequently produce spuriously low sodium values. The third method (direct potentiometry) involves no sample dilution, and sodium measurements are unaffected by hyperlipidemia and hyperproteinemia. As all three methods for sodium measurements may coexist in a clinical laboratory, it is important for the physician to be aware not only of the serum value but also the method employed.
应将假性低钠血症与真性低钠血症区分开来，以免采取不当治疗措施。假性低钠血症是由血清脂质或蛋白质浓度升高导致血清水分被置换引起的。目前用于测量血清钠的三种方法中，只有两种（火焰光度法和间接电位法）涉及样本稀释，因此可能会产生假性低钠值。第三种方法（直接电位法）不涉及样本稀释，钠测量不受高脂血症和高蛋白血症影响。由于临床实验室中可能同时存在这三种钠测量方法，医生不仅要了解血清值，还要知道所采用的方法，这一点很重要。
