Ota Hideo, Hoshino Hiromitsu, Yamashita Shinya, Ikushima Hirofumi, Mizuno Hitoshi
Dept. of Gastroenterological Surgery, Nippon Life Hospital.
Gan To Kagaku Ryoho. 2024 Dec;51(13):1627-1629.
The patient was a 70s-years-old male. Subtotal stomach-preserving pancreaticoduodenectomy and Child modified reconstruction was performed for lower bile duct cancer. Seven months after surgery, the patient developed pulmonary metastasis recurrence, and 9 months after surgery, the soft tissue shadow at the hepatic hilum had increased and portal vein obstruction had occurred, so best supportive care was adopted. Diarrhea began at the 10 months after surgery. 13 months after surgery, the patient was hospitalized with respiratory dysfunction due to malignant pleural effusion. One week after admission, the patient exhibited liver dysfunction and a high fever of 41.0℃; blood cultures were submitted and MEPM/ VCM was initiated, after which the fever subsided tomorrow. Edwardsiella tarda (E. tarda) was detected in the blood culture results obtained 2 days later, and based on the clinical symptoms, the patient was diagnosed with bacteremia resulting from cholangitis due to E. tarda. If recurrence occurs in the hepatic hilum after pancreaticoduodenectomy, intestinal fluid reflux is likely to occur, leading to cholangitis due to E. tarda, and bacteremia can be fatal, so this should be kept in mind as an oncology emergency.
患者为一名70多岁的男性。因低位胆管癌行保留部分胃的胰十二指肠切除术及Child改良重建术。术后7个月,患者出现肺转移复发,术后9个月,肝门部软组织影增大且发生门静脉梗阻,遂采取最佳支持治疗。术后10个月开始出现腹泻。术后13个月,患者因恶性胸腔积液导致呼吸功能障碍入院。入院1周后,患者出现肝功能障碍及41.0℃的高热;送检血培养并开始使用美洛培南/万古霉素,次日热退。2天后获得的血培养结果检测到迟缓爱德华氏菌,根据临床症状,患者被诊断为迟缓爱德华氏菌所致胆管炎引起的菌血症。胰十二指肠切除术后若肝门部复发,很可能发生肠液反流,导致迟缓爱德华氏菌引起的胆管炎,菌血症可能致命,因此应将其作为肿瘤急症牢记。