Kolimas Amie Marie, Malla Gargya, Chadha Abhimanyu, Sainbayar Enkhtsogt, Sethi Joshua, Hindosh Ziad, Hadvani Priyanka, Pham Hoang Nhat, Sordia Juan
Department of Medicine, University of Arizona, Tucson, AZ 85721, United States.
Department of Cardiology, Honor Health, Phoenix, 1625 N Campbell Ave, Tucson, AZ 85719, United States.
Curr Cardiol Rev. 2025;21(5):112-116. doi: 10.2174/011573403X343512250127075044.
Thoracic aortic aneurysms (TAAs) are worrisome for their propensity to dissect. Previous studies have demonstrated the potential benefits of statin use, particularly with slowing aortic aneurysm growth. The aim of this meta-analysis was to consolidate existing research to ascertain if statins effectively reduce TAA growth.
Multiple databases were searched to identify studies assessing TAA growth in patients on statins (cases) and those not on statins (controls). The primary outcome was TAA (ascending/ aortic arch) growth rate per year. Standard mean difference (SMD) and 95% confidence intervals (95% CI) were estimated with a random-effects model using the inverse-variance technique. We assigned I2>50% as an indicator of statistical heterogeneity. P-value <0.05 was considered significant. Data analysis was performed using SPSS v.25.0.
Four studies comprising 757 cases (male 64%, mean age 65±14 years) and 1,696 controls (male 62%, mean age 61±18 years) were included. The baseline diameters of TAA for cases and controls were 40.35±8.75 mm and 42.39±12.60 mm, respectively. Pooled results suggested statins to be associated with slower growth of TAAs with pooled SMD -0.70 mm/year [95% CI (-1.23 - -0.16); p=0.01]. Heterogeneity statistics among 4 studies was 95%.
This pooled meta-analysis showed statins as associated with slower growth of TAAs. However, given the heterogeneity of the included studies in this meta-analysis, results should be interpreted with caution.
胸主动脉瘤（TAA）因其易于夹层形成而令人担忧。先前的研究已经证明了使用他汀类药物的潜在益处，特别是在减缓主动脉瘤生长方面。本荟萃分析的目的是整合现有研究，以确定他汀类药物是否能有效降低TAA的生长速度。
检索多个数据库，以识别评估服用他汀类药物的患者（病例组）和未服用他汀类药物的患者（对照组）中TAA生长情况的研究。主要结局是每年TAA（升主动脉/主动脉弓）的生长速度。采用随机效应模型，使用逆方差技术估计标准平均差（SMD）和95%置信区间（95%CI）。我们将I2>50%作为统计异质性的指标。P值<0.05被认为具有统计学意义。使用SPSS v.25.0进行数据分析。
纳入了4项研究，包括757例病例（男性占64%，平均年龄65±14岁）和1696例对照（男性占62%，平均年龄61±18岁）。病例组和对照组的TAA基线直径分别为40.35±8.75mm和42.39±12.60mm。汇总结果表明，他汀类药物与TAA生长速度较慢有关，汇总SMD为-0.70mm/年[95%CI（-1.23 - -0.16）；p=0.01]。4项研究之间的异质性统计为95%。
这项汇总的荟萃分析表明，他汀类药物与TAA生长速度较慢有关。然而，鉴于本荟萃分析中纳入研究的异质性，对结果的解释应谨慎。
