Puthuraya K P, Oomura Y, Shimizu N
Brain Res. 1985 Apr 15;332(1):165-8. doi: 10.1016/0006-8993(85)90401-9.
Effects of certain endogenous sugar acids such as 2-deoxytetronic acid (2-DTA) and 3-deoxypentonic acid (3-DPA) were investigated on the neuronal activity of the ventromedial hypothalamic nucleus (VMH) in the rat. Electrophoretically applied 2-DTA significantly and specifically facilitated the activity of glucoreceptor neurons in the VMH, while 3-DPA suppressed their activity. However, non-glucoreceptor neurons were not affected by these sugar acids. These results reinforces the previous suggestion that 2-DTA and 3-DPA also might act as endogenous satiety and hunger substances, respectively.
