Pérez Reiner R, Arroyo J L, LLorens R, Alegría E, Carrascosa F, Pezonaga L, González Esparza L
Rev Med Univ Navarra. 1979 Dec;23(4):45-9.
The endocrine, humoral and hemodynamic factors that affect renin secretion are studied during open-heart surgery in a group of 40 patients, 20 with mitral and 20 with aortic valve disease. During the incission period, the PRA (plasma renin activity) increases due to a sympatoadrenergic hyperactivity. These increase is noted also during bypass, and is closely related with the hypotension that extracorporeal circulation produces. It is also discussed the influence of the exclusion of pulmonary circulation, that decreases conversion of angiotensin I to II and catabolism of norepinephrine.
在一组40例患者（20例二尖瓣疾病患者和20例主动脉瓣疾病患者）的心脏直视手术期间，研究了影响肾素分泌的内分泌、体液和血流动力学因素。在切开期，由于交感肾上腺素能活性亢进，血浆肾素活性（PRA）升高。在体外循环期间也观察到这种升高，并且与体外循环产生的低血压密切相关。还讨论了肺循环排除的影响，这会减少血管紧张素I向II的转化以及去甲肾上腺素的分解代谢。
