Semantic memory structure mediates the role of brain functional connectivity in creative writing.

Associative theories of creativity posit that high-creativity individuals possess flexible semantic memory structures that allow broad access to varied information. However, the semantic memory structure characteristics and neural substrates of creative writing are unclear. Here, we explored the semantic network features and the predictive whole-brain functional connectivity associated with creative writing and generated mediation models. Participants completed two creative story continuation tasks. We found that keywords from written texts with superior creative writing performance encompassed more semantic categories and were highly interconnected and transferred efficiently. Connectome predictive modeling (CPM) was conducted with resting-state functional magnetic resonance imaging (fMRI) data to identify whole-brain functional connectivity patterns related to creative writing, dominated by default mode network (DMN). Semantic network features were found to mediate the relationship between brain functional connectivity and creative writing performance. These results highlight how semantic memory structure and the DMN-driven brain functional connectivity patterns support creative writing performance. Our findings extend prior research on the role of semantic memory structure and the DMN in creativity, expand upon previous research on semantic creativity, and provide insight into the cognitive and neural foundations of creative writing.