肿瘤细胞可塑性与基质微环境在BRAFV600E诱导的甲状腺癌小鼠模型中区分乳头状和滤泡状生长模式。

Tumor Cell Plasticity and Stromal Microenvironment Distinguish Papillary and Follicular Growth Patterns in a Mouse Model of BRAFV600E-Induced Thyroid Cancer.

作者信息

Schoultz Elin, Moccia Carmen, Liang Shawn, Johansson Ellen, Nilsson Mikael

机构信息

Sahlgrenska Center for Cancer Research, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden.

Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden.

出版信息

Cancer Res Commun. 2025 Mar 1;5(3):409-421. doi: 10.1158/2767-9764.CRC-24-0474.

Cell-of-origin intrinsic features rather than driver mutation identity influence tumor growth patterning in differentiated thyroid cancer and might impact histopathologic diagnosis of thyroid carcinoma subtypes.