Holka-Pokorska Justyna, Kucharski Adam
Department of Pharmacology and Physiology of CNS, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland.
Faculty of Psychology, University of Szczecin, 70-453 Szczecin, Poland.
Sex Med. 2025 Feb 15;13(1):qfaf006. doi: 10.1093/sexmed/qfaf006. eCollection 2025 Feb.
The hormonal composition of amniotic fluid during prenatal development, particularly the androgen-to-estrogen ratio, may influence neuronal differentiation related to sexual response patterns and the capacity to control impulsive sexual behaviors in later life.
This study aims to assess sexual behaviors and characterize sexual responses in women with borderline personality disorder (BPD) compared to a control group.
The study included 33 women diagnosed with BPD and 56 women in a control group. BPD diagnoses were based on clinical psychiatric evaluation and the Structured Clinical Interview for DSM-IV. Elements of sexual response were measured using the Arizona Sexual Experience Scale (ASEX). The digit ratio (2D:4D) served as a biomarker for testosterone and estrogen exposure during early prenatal development.
ASEX results were analyzed in the categories of "desire," "arousal," and "vaginal lubrication" subscales, along with the 2D:4D digit ratio for both hands.
Lower values for the right-hand digit ratio were observed in the BPD group compared to the control group (0.989, SD = 0.034 vs. 1.016, SD = 0.039; = 0.0014), potentially indicating higher prenatal testosterone levels. Significant correlations were found in the BPD group between the right-hand digit ratio and scores on the ASEX subscales, specifically "sexual arousal" ( = 0.406, = 0.019) and "vaginal lubrication" ( = 0.362, = 0.038).
These results may support biological hypotheses regarding the origins of sexual dysfunction in women with BPD.
This study is a pioneering attempt to explore the indirect impact of early amniotic hormone composition on the neurobiological conditioning of sexual response and behavior in women with BPD. Limitations include the preliminary nature of the findings, a small sample size, and results that may not be generalizable across all genders.
Physiological aspects of sexual response, such as arousal and vaginal lubrication, in women with BPD appear to be significantly correlated with prenatal testosterone levels, as indicated by the 2D:4D digit ratio.
产前发育期间羊水的激素组成，尤其是雄激素与雌激素的比例，可能会影响与性反应模式相关的神经元分化以及日后控制冲动性行为的能力。
本研究旨在评估边缘型人格障碍（BPD）女性与对照组相比的性行为，并对其性反应进行特征描述。
该研究纳入了33名被诊断为BPD的女性和56名对照组女性。BPD诊断基于临床精神病学评估和《精神疾病诊断与统计手册第四版》的结构化临床访谈。使用亚利桑那性经验量表（ASEX）测量性反应的各项指标。指长比（2D:4D）作为产前早期睾酮和雌激素暴露的生物标志物。
对ASEX结果在“欲望”“唤起”和“阴道润滑”分量表类别中进行分析，并分析双手的2D:4D指长比。
与对照组相比，BPD组右手指长比的值更低（0.989，标准差 = 0.034对1.016，标准差 = 0.039；P = 0.0014），这可能表明产前睾酮水平较高。在BPD组中，右手指长比与ASEX分量表得分之间存在显著相关性，特别是“性唤起”（P = 0.406，P = 0.019）和“阴道润滑”（P = 0.362，P = 0.038）。
这些结果可能支持关于BPD女性性功能障碍起源的生物学假说。
本研究是探索早期羊水激素组成对BPD女性性反应和行为的神经生物学影响的开创性尝试。局限性包括研究结果的初步性质、样本量小以及结果可能不适用于所有性别。
如2D:4D指长比所示，BPD女性的性反应生理方面，如唤起和阴道润滑，似乎与产前睾酮水平显著相关。
