Rissaadah Siti, Nursiswati Nursiswati, Pahria Tuti
Master of Nursing Study Program, Faculty of Nursing, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Department of Medical-Surgical Nursing, Faculty of Nursing, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
J Multidiscip Healthc. 2025 Feb 11;18:747-758. doi: 10.2147/JMDH.S510247. eCollection 2025.
Type 2 diabetes mellitus (T2DM), characterized by chronic hyperglycemia, leads to a decreased immune system and increased susceptibility to infections, such as tuberculosis (TB). However, there are gaps in comprehensive reviews on the relationship between TB and the severity of glycemic control in patients with T2DM, characteristics of glycemic levels, and clinical treatment among patients with DM-TB.
The primary aim of this study is to explore the association of DM-TB and glycemic control. The secondary aim of this study was to explore the association between DM-TB, successful treatment, and TB severity.
This study used a scoping review following the Arksey and O'Malley framework to provide an overview of glycemic control and clinical treatment of DM-TB. A literature search was performed using three databases, PubMed, Scopus, and Medline, with inclusion criteria for the population of patients with diabetes mellitus and tuberculosis who discuss glycemic control and clinical treatment. Critical appraisal in this study was assessed using the Joanna-Briggs Institute (JBI) critical appraisal tools.
We included 16 studies from a total of 741 articles in the initial search. The results of this study showed that patients with DM-TB were more likely to have poor glycemic control than those with diabetes mellitus (DM) without TB. Severe hyperglycemia in patients with DM-TB is associated with an increased risk of TB treatment failure, a long recovery time, and the likelihood of developing multi-drug-resistant tuberculosis (MDR-TB). In addition, patients with DM-TB who did not start TB treatment were more likely to have poorer glycemic control than patients with DM-TB who underwent active TB treatment.
Patients with DM-TB, such as MDR-TB, are at a higher risk of poor glycemic control, treatment failure, and clinical severity. Adequate treatment, such as a continuum of glycemic monitoring and early detection and intervention for TB, is needed to improve treatment outcomes.
2型糖尿病（T2DM）以慢性高血糖为特征，会导致免疫系统下降以及对感染（如结核病）的易感性增加。然而，关于结核病与T2DM患者血糖控制的严重程度、血糖水平特征以及糖尿病合并结核病患者的临床治疗之间关系的综合综述仍存在空白。
本研究的主要目的是探讨糖尿病合并结核病（DM-TB）与血糖控制之间的关联。本研究的次要目的是探讨DM-TB、成功治疗与结核病严重程度之间的关联。
本研究采用遵循阿克西和奥马利框架的范围综述，以概述DM-TB的血糖控制和临床治疗情况。使用三个数据库（PubMed、Scopus和Medline）进行文献检索，纳入标准为讨论血糖控制和临床治疗的糖尿病和结核病患者群体。本研究中的批判性评价使用乔安娜-布里格斯研究所（JBI）批判性评价工具进行评估。
在初步检索的741篇文章中，我们纳入了16项研究。本研究结果表明，与无结核病的糖尿病（DM）患者相比，DM-TB患者血糖控制不佳的可能性更高。DM-TB患者的严重高血糖与结核病治疗失败风险增加、恢复时间延长以及发生耐多药结核病（MDR-TB）的可能性相关。此外，未开始结核病治疗的DM-TB患者比接受活动性结核病治疗的DM-TB患者血糖控制更差的可能性更高。
DM-TB患者，如MDR-TB患者，血糖控制不佳、治疗失败和临床严重程度的风险更高。需要进行充分的治疗，如持续的血糖监测以及对结核病的早期检测和干预，以改善治疗效果。
