高葡萄糖对三羧酸循环的贡献是侵袭性非小细胞肺癌患者的一个特征。
High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients.
作者信息
Cai Ling, Hammond Nia G, Tasdogan Alpaslan, Alsamraae Massar, Yang Chendong, Cameron Robert B, Quan Peiran, Solmonson Ashley, Gu Wen, Pachnis Panayotis, Kaur Mayher, Chang Brianna K, Zhou Qin, Hensley Christopher T, Do Quyen N, Martins Nascentes Melo Luiza, Ubellacker Jessalyn M, Kaushik Akash, Clare Maia G, Alcazar Isabel N, Kurylowicz Katarzyna, Marcuccilli Joseph D, Allies Gabriele, Kutritz Andrea, Klode Joachim, Ramesh Vijayashree, Rogers Thomas J, Rao Aparna D, Crentsil Hannah E, Li Hong, Brister Fang, McDaniel Phyllis, Xu Xiaohong, Evers Bret M, Zacharias Lauren G, Sudderth Jessica, Xu Jian, Mathews Thomas P, Oliver Dwight, Minna John D, Waters John, Morrison Sean J, Kernstine Kemp H, Faubert Brandon, DeBerardinis Ralph J
机构信息
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas.
Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas.
出版信息
Cancer Discov. 2025 Apr 2;15(4):702-716. doi: 10.1158/2159-8290.CD-23-1319.
Intraoperative 13C-glucose infusions in patients with NSCLC show that tumors with high labeling of TCA cycle intermediates progress rapidly, resulting in metastasis and early death. Blocking this pathway suppresses metastasis of human NSCLC cells in mice.
非小细胞肺癌患者术中输注13C-葡萄糖显示，三羧酸循环中间体标记高的肿瘤进展迅速，导致转移和早期死亡。阻断该途径可抑制人非小细胞肺癌细胞在小鼠体内的转移。
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