Merkow Ryan P, Cavnar Michael J, Gleisner Ana L, Mayo Skye C, Gholami Sepideh, Karanicolas Paul J, Koerkamp Bas Groot, Homs Marjolein Y V, Connell Louise C, Cercek Andrea, Helft Paul R, Polite Blase N, Patel Reema A, Uronis Hope E, D'Angelica Michael, Lidsky Michael E
Department of Surgery, Division of Surgical Oncology, University of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Department of Surgery, Division of Surgical Oncology, University of Kentucky, Lexington, KY, USA.
Ann Surg Oncol. 2025 Jun;32(6):4408-4416. doi: 10.1245/s10434-025-17009-1. Epub 2025 Feb 17.
Hepatic arterial infusion (HAI) pump chemotherapy is an effective therapy for colorectal liver metastases and intrahepatic cholangiocarcinoma. In the setting of recent reports suggesting favorable outcomes in these diseases with HAI, there has been a surge in interest in this treatment worldwide, prompting the opening of many new HAI programs. While significant technical expertise is required for pump implantation, this alone is insufficient to open a safe and sustainable HAI program, and numerous other factors must be considered prior to the first pump implantation. This expert perspective, established using an anonymous web-based survey of experienced multidisciplinary international HAI providers, details the minimum required personnel, expertise, training, and infrastructure to optimize success and sustainability of a safe and effective new HAI program.
肝动脉灌注(HAI)泵化疗是治疗结直肠癌肝转移和肝内胆管癌的有效方法。近期有报道称HAI治疗这些疾病效果良好,这引发了全球对该治疗方法的兴趣激增,促使许多新的HAI项目纷纷开展。虽然泵植入需要高超的技术专长,但仅这一点不足以开展一个安全且可持续的HAI项目,在首次进行泵植入之前,还必须考虑许多其他因素。本专家观点通过对经验丰富的多学科国际HAI提供者进行匿名网络调查得出,详细阐述了开展一个安全有效的新HAI项目并实现成功与可持续性所需的最低人员配备、专业知识、培训及基础设施。