Jayte Mohamed, Jama Yahye Mohamed, Athanus Lubega
Internal Medicine Department at Kampala International University, Kampala, Uganda.
Internal Medicine Department at Itogo General Hospital, Itogo, Uganda.
Int Med Case Rep J. 2025 Feb 13;18:249-253. doi: 10.2147/IMCRJ.S508884. eCollection 2025.
Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI), is widely prescribed in antiretroviral therapy (ART) for HIV treatment. Although effective, it is associated with rare but severe adverse drug reactions, including Stevens-Johnson syndrome (SJS), a life-threatening mucocutaneous disorder. This case report describes a Middle age HIV-positive man who developed SJS following nevirapine initiation, highlighting the importance of timely recognition, management, and the need for clinician vigilance to prevent adverse outcomes in antiretroviral therapy.
奈韦拉平是一种非核苷类逆转录酶抑制剂（NNRTI），在抗逆转录病毒疗法（ART）中被广泛用于治疗HIV。尽管它有效，但会引发罕见却严重的药物不良反应，包括史蒂文斯 - 约翰逊综合征（SJS），这是一种危及生命的皮肤黏膜疾病。本病例报告描述了一名中年HIV阳性男性在开始使用奈韦拉平后出现SJS的情况，强调了及时识别、处理的重要性以及临床医生在抗逆转录病毒治疗中保持警惕以预防不良后果的必要性。
