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伊伐布雷定用于法洛四联症修复术后1岁儿童的持续性房性心动过速

Ivabradine for Incessant Atrial Tachycardia in a 1-Year-Old Child After Tetralogy of Fallot Repair.

作者信息

Balweel Haikal, Sukardi Rubiana, Marwali Eva Miranda, Eri Rifqi Rizkani, Tafriend Novaro Adeneur, Harsoyo Agus

机构信息

Department of Cardiology, Gatot Soebroto Army Central Hospital, Jakarta, Indonesia.

Department of Cardiology, Jakarta Heart Center, Jakarta, Indonesia.

出版信息

Case Rep Cardiol. 2025 Feb 10;2025:2601345. doi: 10.1155/cric/2601345. eCollection 2025.

Abstract

: Ivabradine is a novel drug with the ability to reduce heart rate without compromising myocardial contractility or blood pressure. Studies on this drug exist mainly for heart failure and coronary artery disease; for arrhythmia, the studies are limited to small sample trials and case series, mostly unrandomized. Additionally, its evidence for arrhythmia in pediatric patients is limited. Here, we present a case of successful ivabradine administration for incessant atrial tachycardia in a 1-year-old child following tetralogy of Fallot (TOF) repair. : A 1-year-old child experienced incessant tachyarrhythmia episodes after TOF repair. Multiple standard therapies, including adenosine, amiodarone, multiple cardioversions, beta-blockers, and digoxin, failed to convert the rhythm. Considering the limited therapy options and existing case reports, ivabradine was administered at a dose of 0.1 mg/kg. Subsequently, sinus rhythm was restored 8 h after its administration, with the heart rate significantly decreased, and the patient returned to a stable hemodynamic status. : Ivabradine may be an option for incessant atrial tachycardia in pediatric patients. Although most tachyarrhythmias following TOF repair occur due to a reentry mechanism, focal mechanisms can also occur, suggested by timing, gradual acceleration after cardioversion and its response to ivabradine. Future studies are needed to further understand the safety and efficacy of ivabradine for atrial tachycardia in pediatric patients.

摘要

伊伐布雷定是一种新型药物,能够降低心率,同时不影响心肌收缩力或血压。关于这种药物的研究主要集中在心力衰竭和冠状动脉疾病方面;对于心律失常,相关研究仅限于小样本试验和病例系列,大多未进行随机分组。此外,其在儿科患者心律失常方面的证据有限。在此,我们报告一例法洛四联症(TOF)修复术后1岁儿童使用伊伐布雷定成功治疗持续性房性心动过速的病例。

一名1岁儿童在TOF修复术后出现持续性快速心律失常发作。包括腺苷、胺碘酮、多次心脏复律、β受体阻滞剂和地高辛在内的多种标准治疗均未能转复心律。考虑到治疗选择有限以及现有病例报告,给予伊伐布雷定,剂量为0.1mg/kg。随后,给药8小时后恢复窦性心律,心率显著下降,患者恢复至稳定的血流动力学状态。

伊伐布雷定可能是儿科患者持续性房性心动过速的一种治疗选择。尽管TOF修复术后大多数快速心律失常是由折返机制引起的,但根据发作时间、心脏复律后逐渐加速以及对伊伐布雷定的反应提示,也可能存在局灶性机制。需要进一步的研究来深入了解伊伐布雷定在儿科患者房性心动过速治疗中的安全性和有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84be/11832250/7523eb4cf267/CRIC2025-2601345.001.jpg

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