短期热量限制或补充白藜芦醇会改变雄性和雌性大鼠的大规模脑网络连通性。

Short-term caloric restriction or resveratrol supplementation alters large-scale brain network connectivity in male and female rats.

作者信息

van Rooij Judith R A, van den Berg Monica, Vasilkovska Tamara, Van Audekerke Johan, Kosten Lauren, Bertoglio Daniele, Adhikari Mohit H, Verhoye Marleen

机构信息

Bio-Imaging Lab, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.

μNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium.

出版信息

Front Nutr. 2025 Feb 3;12:1440373. doi: 10.3389/fnut.2025.1440373. eCollection 2025.

DOI:10.3389/fnut.2025.1440373

PMID:39963669

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11830597/

Abstract

INTRODUCTION

Dietary interventions such as caloric restriction (CR) exert positive effects on brain health. Unfortunately, poor compliance hinders the success of this approach. A proposed alternative is resveratrol (Rsv), a CR-mimetic known to promote brain health. Direct comparison between the effects of Rsv and CR on brain health is lacking, with limited knowledge on their sex-specific effects. Therefore, we aimed to compare and unravel the sex-specific impact of these dietary interventions on spontaneous brain activity.

METHODS

Here, we used resting-state fMRI to investigate functional connectivity (FC) changes in five prominent resting-state brain networks (RSNs) in healthy 4 month old male and female F344 rats supplemented to either 40% CR or daily Rsv supplementation (10 mg/kg, oral) for the duration of 1 month.

RESULTS

Our results demonstrated a decreased body weight (BW) in CR rats, as well as an increase in body weight in male Rsv supplemented rats, compared to female Rsv supplemented rats, whereas this difference between sexes was not observed in the control or CR groups. Furthermore, we found that both CR or Rsv supplementation induce a female-specific decrease of FC between the subcortical network and hippocampal network, and between the subcortical network and lateral cortical network. Moreover, Rsv supplementation lowered FC within the hippocampal network and between the hippocampal and the default mode like network, the lateral cortical network and the sensory network-an effect not observed for the CR rats.

DISCUSSION

Our findings reveal that both CR and Rsv induce a similar female-specific decrease of FC in RSNs associated with memory and emotion, all the while CR and Rsv induce dissimilar changes in body weight and other within- and between-RSN FC measures. Altogether, this study provides insight into the effects and comparability of short-term CR and Rsv supplementation on brain connectivity within- and between-RSNs in both male and female F344 rats, providing a FC reference for future research of dietary effects.

摘要

引言

诸如热量限制（CR）等饮食干预措施对大脑健康具有积极影响。不幸的是，依从性差阻碍了这种方法的成功实施。一种提议的替代方法是白藜芦醇（Rsv），一种已知可促进大脑健康的模拟热量限制物质。目前缺乏Rsv和CR对大脑健康影响的直接比较，且对它们的性别特异性影响了解有限。因此，我们旨在比较并阐明这些饮食干预措施对自发脑活动的性别特异性影响。

方法

在此，我们使用静息态功能磁共振成像（fMRI）来研究健康的4个月大雄性和雌性F344大鼠在补充40%热量限制或每日补充Rsv（10毫克/千克，口服）1个月后，五个主要静息态脑网络（RSN）中的功能连接（FC）变化。

结果

我们的结果表明，与补充Rsv的雌性大鼠相比，CR大鼠体重下降，而补充Rsv的雄性大鼠体重增加，而在对照组或CR组中未观察到这种性别差异。此外，我们发现补充CR或Rsv均会导致皮质下网络与海马网络之间以及皮质下网络与外侧皮质网络之间的FC出现女性特异性降低。此外，补充Rsv会降低海马网络内以及海马与默认模式样网络、外侧皮质网络和感觉网络之间的FC，而CR大鼠未观察到这种效应。

讨论

我们的研究结果表明，CR和Rsv均会导致与记忆和情绪相关的RSN中出现类似的女性特异性FC降低，同时CR和Rsv在体重以及其他RSN内和RSN间FC测量方面会引起不同的变化。总之，本研究深入探讨了短期CR和Rsv补充对雄性和雌性F344大鼠RSN内和RSN间脑连接性的影响及可比性，为未来饮食效应研究提供了FC参考。