Skaarup Kristoffer Grundtvig, Davidovski Filip Soeskov, Durukan Emil, Modin Daniel, Lassen Mats Christian Højbjerg, Dons Maria, Jensen Anne Marie Reimer, Johansen Niklas Dyrby, Sengeløv Morten, Vyff Frederikke, Landler Nino Emanuel, Jensen Gorm Boje, Nielsen Anne Bjerg, Christensen Jacob, Hauser Raphael, Schnohr Peter, Møgelvang Rasmus, Nielsen Lene, Jensen Jens-Ulrik Stæhr, Biering-Sørensen Tor
Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark.
Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Influenza Other Respir Viruses. 2025 Feb;19(2):e70067. doi: 10.1111/irv.70067.
Influenza infection has been associated with multiple cardiac complications including acute heart failure and myocardial infarction. The FluHeart study aims to uncover the potential effect of influenza infection on cardiac structure and function as assessed by echocardiography during hospitalization.
This prospective cohort study included hospitalized influenza patients of the 2021-2022 influenza season. Participants underwent echocardiography using a prespecified protocol. Participants were successfully matched 1:1:1 on age, sex, and heart failure status with controls from the general population and controls hospitalized with COVID-19.
This interim analysis involved 108 participants (36 influenza patients, 36 general population controls, and 36 COVID-19 patients). Mean age was 72 ± 18 years and 58% were male. Median time from admission to echocardiography was 1 day (IQI: 1:1) for influenza patients. The prevalence of left ventricular (LV) dysfunction was 75%, and right ventricular (RV) dysfunction was observed in 20% of influenza patients. N-terminal pro-brain natriuretic peptide levels were elevated ≥ 300 pg/mL in 62%, and 19% exhibited myocardial injury with elevated high-sensitivity troponin I levels. RV tricuspid annular plane systolic excursion and LV early diastolic peak mitral inflow to early diastolic tissue velocity were significantly worse in influenza patients compared to general population controls. Echocardiographic measures did not significantly differ between patients hospitalized with influenza and COVID-19.
In this interim analysis of the FluHeart study, both RV and LV function measures were significantly impaired in hospitalized influenza patients compared with matched general population controls. The extent of impairment resembled that observed in hospitalized COVID-19 patients.
流感感染与多种心脏并发症有关，包括急性心力衰竭和心肌梗死。FluHeart研究旨在揭示流感感染对住院期间通过超声心动图评估的心脏结构和功能的潜在影响。
这项前瞻性队列研究纳入了2021-2022流感季节住院的流感患者。参与者按照预先指定的方案接受超声心动图检查。参与者在年龄、性别和心力衰竭状态方面与来自普通人群的对照组以及因COVID-19住院的对照组成功进行了1:1:1匹配。
这项中期分析涉及108名参与者（36名流感患者、36名普通人群对照组和36名COVID-19患者）。平均年龄为72±18岁，58%为男性。流感患者从入院到进行超声心动图检查的中位时间为1天（四分位间距：1:1）。左心室（LV）功能障碍的患病率为75%，20%的流感患者观察到右心室（RV）功能障碍。62%的患者N末端脑钠肽前体水平升高≥300 pg/mL，19%的患者表现出心肌损伤，高敏肌钙蛋白I水平升高。与普通人群对照组相比，流感患者的右心室三尖瓣环平面收缩期位移和左心室舒张早期二尖瓣流入血流速度与舒张早期组织速度比值明显更差。流感患者和COVID-19患者的超声心动图测量结果没有显著差异。
在FluHeart研究的这项中期分析中，与匹配的普通人群对照组相比，住院流感患者的右心室和左心室功能指标均显著受损。受损程度与COVID-19住院患者中观察到的相似。
