Mudiyanselage Sriyani Padmalatha Konara, Tsai Yi-Tseng, Liu Wen-Chun, Tsai Yi-Jing, Ko Nai-Ying
Institute of Behavioral Medicine, The National Cheng Kung University, Tainan, Taiwan; Operation theater department, The National hospital of Sri Lanka, Colombo, Sri Lanka; Department of Nursing, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Nursing, An Nan Hospital, China Medical University, Tainan, Taiwan.
J Affect Disord. 2025 May 1;376:422-434. doi: 10.1016/j.jad.2025.02.027. Epub 2025 Feb 16.
Suicidal behaviours, including ideation, attempts, and mortality, are significant yet often overlooked concerns among women with breast cancer. While the psychological burden of breast cancer has been studied, comprehensive data on the prevalence and risk factors of suicidal behaviours in this population remain limited.
This systematic review and meta-analysis aim to assess the prevalence, incidence, and risk factors associated with suicidal behaviours among women with breast cancer.
A literature search was conducted using Embase, MEDLINE, CINAHL, Web of Science, and Academic Search Complete for studies published up to June 2024. Search terms included 'breast cancer,' 'suicidal behaviour,' 'suicide ideation,' 'suicide attempts,' 'self-harm,' and 'self-injury.' Eligible studies included primary data on suicidal ideation, attempts, or completed suicides among women with breast cancer. Meta-analyses were performed using random-effects models, and heterogeneity was assessed with the I statistic.
Twenty studies comprising 3450,022 participants were included. The pooled prevalence of suicidal ideation was 10 % (95 % CI 0.01-0.63, p < 0.001), while suicide attempts were reported at 2 % (95 % CI 0.01-0.03, p < 0.001). Suicide mortality was observed in 0.001 % (95 % CI 0.001-0.002, p < 0.001). Younger age (18-45 years), advanced cancer stages (stage IV), and unmarried status were significant risk factors.
Suicidal behaviours are prevalent among women with breast cancer, particularly in younger, unmarried patients with advanced cancer stages. Comprehensive mental health support is crucial in reducing suicide risk.
自杀行为，包括自杀意念、自杀未遂和自杀死亡，是乳腺癌女性中重要但常被忽视的问题。虽然乳腺癌的心理负担已得到研究，但关于该人群自杀行为的患病率和危险因素的全面数据仍然有限。
本系统评价和荟萃分析旨在评估乳腺癌女性自杀行为的患病率、发病率及相关危险因素。
使用Embase、MEDLINE、CINAHL、Web of Science和Academic Search Complete对截至2024年6月发表的研究进行文献检索。检索词包括“乳腺癌”“自杀行为”“自杀意念”“自杀未遂”“自我伤害”和“自我损伤”。符合条件的研究包括乳腺癌女性自杀意念、自杀未遂或自杀死亡的原始数据。采用随机效应模型进行荟萃分析，并用I统计量评估异质性。
纳入20项研究，共3450022名参与者。自杀意念的合并患病率为10%（95%CI 0.01 - 0.63，p < 0.001），自杀未遂报告率为2%（95%CI 0.01 - 0.03，p < 0.001）。自杀死亡率为0.001%（95%CI 0.001 - 0.002，p < 0.001）。年龄较小（18 - 45岁）、癌症晚期（IV期）和未婚状态是显著的危险因素。
自杀行为在乳腺癌女性中普遍存在，尤其是在年龄较小、未婚且处于癌症晚期的患者中。全面的心理健康支持对于降低自杀风险至关重要。
