Liu Ke-Peng, Huang Hua-Qing, Li Bin-Fei, Pan Ling-Li, Liu Pei-Chang, Lin Nan, Lan Jian-Ning, Liao Zhen-Qi, Huang Ya-Qi, Chen Xiu-Ru, Li Xiao-Ting, Luo Hui-Rong, Lai Zhong-Meng
Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian Province 350001, China; Department of Anesthesiology, Zhongshan City People's Hospital, Zhongshan, Guangdong Province, China.
Department of Anesthesiology, Fujian Medical University Union Hospital, 29 Xin-Quan Road, Fuzhou, Fujian Province 350001, China; Department of Pain Medicine, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian Province, China.
J Affect Disord. 2025 May 15;377:77-84. doi: 10.1016/j.jad.2025.02.017. Epub 2025 Feb 16.
Environmental factors such as pollution have been reported to deteriorate sleep quality. Ethylene oxide (EO), a reactive cyclic oxide commonly used in manufacturing processes, has been associated with various health concerns such as cancer, metabolic syndrome, and inflammatory conditions. However, the relationship between EO exposure and self-reported troubled sleeping remains unclear. Using the National Health and Nutrition Examination Survey (NHANES) data from 2013 to 2018, 4310 participants with EO exposure histories were analyzed. Three groups of participants were categorized according to log2-transformed levels of hemoglobin adducts of the EO (HbEO). The risk of trouble sleeping was assessed using logistic regression, restricted cubic spline regression modeling, and subgroup analysis. Over the tertiles of HbEO levels, the prevalence of trouble sleeping prevalence increased from 28 % to 29 % to 35 %. Log2-transformed HbEO levels were significantly associated with an increased risk of trouble sleeping after adjusting for all covariates (Tertile 3 vs. Tertile 1 in model 4: OR = 1.41, 95 % CI: 1.07-1.86, P = 0.018, P for trend = 0.025). Additionally, a nonlinear J-shaped relationship was observed between HbEO levels and trouble sleeping. Furthermore, HbEO levels were positively correlated with trouble sleeping among different subgroups. Within the 40-60 age bracket, a distinct positive correlation emerged between HbEO levels and trouble sleeping (OR = 1.19, 95 % CI: 1.09-1.3, P = 0.0013). The results indicate a strong link between higher blood HbEO levels and an increased likelihood of sleep disturbances in U.S. adults, especially among those aged 40 to 60 years.
据报道，污染等环境因素会降低睡眠质量。环氧乙烷（EO）是一种常用于制造过程的活性环氧化物，与癌症、代谢综合征和炎症等各种健康问题有关。然而，EO暴露与自我报告的睡眠问题之间的关系仍不清楚。利用2013年至2018年的美国国家健康和营养检查调查（NHANES）数据，对4310名有EO暴露史的参与者进行了分析。根据EO血红蛋白加合物（HbEO）的对数2转换水平，将参与者分为三组。使用逻辑回归、受限立方样条回归模型和亚组分析评估睡眠问题的风险。在HbEO水平的三分位数中，睡眠问题的患病率从28%增加到29%，再到35%。在调整所有协变量后，对数2转换后的HbEO水平与睡眠问题风险增加显著相关（模型4中，三分位数3与三分位数1相比：OR = 1.41，95% CI：1.07 - 1.86，P = 0.018，趋势P = 0.025）。此外，观察到HbEO水平与睡眠问题之间存在非线性J形关系。此外，在不同亚组中，HbEO水平与睡眠问题呈正相关。在40 - 60岁年龄组中，HbEO水平与睡眠问题之间出现了明显的正相关（OR = 1.19，95% CI：1.09 - 1.3，P = 0.0013）。结果表明，美国成年人血液中较高的HbEO水平与睡眠障碍可能性增加之间存在密切联系，尤其是在40至60岁的人群中。
