Lemaeva A A, Gulidov I A
Resident; A. Tsyb Medical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 4 Koroleva St., Obninsk, 249036, Russia.
MD, DSc, Professor, Head of the Radiotherapy Department; A. Tsyb Medical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 4 Koroleva St., Obninsk, 249036, Russia.
Sovrem Tekhnologii Med. 2023;15(5):44-52. doi: 10.17691/stm2023.15.5.05. Epub 2023 Oct 30.
Chordomas and chondrosarcomas of the skull base are rare tumors. They are located in close proximity to critical structures, which poses a serious problem in the treatment of these tumors. Despite advances in surgery, radical resection is often not possible. Radiation therapy for chordomas and chondrosarcomas of the skull base is able to improve overall survival and local control. is to analyze the literature data and evaluate the efficacy of radiation therapy techniques for chordomas and chondrosarcomas of the skull base. The most promising methods of radiation therapy for chordomas and chondrosarcomas of the skull base have been shown to be pencil-beam scanning proton therapy with intensity modulation and carbon ion therapy. These techniques have demonstrated high local control and overall survival with a low incidence of severe radiation-induced toxicity, which confirms their clinical benefits. It has also been found that stereotactic radiosurgery can be effectively used for small tumors (less than 7 cm).
颅底脊索瘤和软骨肉瘤是罕见肿瘤。它们位于关键结构附近，这给这些肿瘤的治疗带来了严重问题。尽管手术有进展，但根治性切除往往无法实现。颅底脊索瘤和软骨肉瘤的放射治疗能够提高总生存率和局部控制率。目的是分析文献数据并评估颅底脊索瘤和软骨肉瘤放射治疗技术的疗效。已证明，对于颅底脊索瘤和软骨肉瘤，最有前景的放射治疗方法是调强笔形束扫描质子治疗和碳离子治疗。这些技术已显示出高局部控制率和总生存率，且严重放射诱导毒性发生率低，这证实了它们的临床益处。还发现立体定向放射外科可有效用于小肿瘤（小于7厘米）。
