Suppr超能文献

实体器官移植受者的衰弱与感染

Frailty and Infection in Solid-Organ Transplant Recipients.

作者信息

Taimur Sarah, Ison Michael G, Baddley John W, Abidi Maheen Z

机构信息

Department of medicine Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Bethesda, Maryland, USA.

出版信息

Transpl Infect Dis. 2025 Mar-Apr;27(2):e14445. doi: 10.1111/tid.14445. Epub 2025 Feb 19.

Abstract

BACKGROUND

The association between frailty and infection in the transplant population is not well understood. Emerging data suggests that frailty at the time of transplant is associated with increased infection risk in liver and older kidney transplant recipients.

METHODS

The authors conducted a brief electronic survey of transplant infectious disease (TID) clinicians, to assess clinical practice trends on frailty assessment.

RESULTS

Among survey participants, only 40% reported a routine assessment of frailty in transplant candidates and recipients at their institutions, most commonly in liver transplant patients. The majority of respondents (77%) reported not being routinely involved in making clinical decisions utilizing frailty information. Seventy-one percent reported interest in the study of frailty in relation to infections in the transplant host.

CONCLUSION

In this survey of TID clinicians, less than half reported a formal frailty assessment for candidates and recipients at their institutions. TID clinicians are mostly not involved in making clinical decisions related to frailty; however, the majority endorsed interest in frailty and infection research. We need future studies to enhance our understanding of the emerging data on the association between frailty and infection risk in the transplant host.

摘要

背景

移植人群中虚弱与感染之间的关联尚未得到充分理解。新出现的数据表明,移植时的虚弱与肝移植受者及老年肾移植受者感染风险增加有关。

方法

作者对移植传染病(TID)临床医生进行了一项简短的电子调查,以评估虚弱评估的临床实践趋势。

结果

在调查参与者中,只有40%报告在其机构对移植候选者和受者进行常规的虚弱评估,最常见于肝移植患者。大多数受访者(77%)报告未常规参与利用虚弱信息做出临床决策。71%报告对研究移植宿主中虚弱与感染的关系感兴趣。

结论

在这项对TID临床医生的调查中,不到一半的人报告在其机构对候选者和受者进行正式的虚弱评估。TID临床医生大多未参与做出与虚弱相关的临床决策;然而,大多数人支持对虚弱和感染研究感兴趣。我们需要未来的研究来增进我们对移植宿主中虚弱与感染风险之间关联的新出现数据的理解。

相似文献

1
Frailty and Infection in Solid-Organ Transplant Recipients.
Transpl Infect Dis. 2025 Mar-Apr;27(2):e14445. doi: 10.1111/tid.14445. Epub 2025 Feb 19.
2
Impact of pre-existing frailty on survival outcomes in solid-organ transplant candidates and recipients: A meta-analysis.
Ageing Res Rev. 2024 Aug;99:102364. doi: 10.1016/j.arr.2024.102364. Epub 2024 Jun 3.
3
Interventions for preventing thrombosis in solid organ transplant recipients.
Cochrane Database Syst Rev. 2021 Mar 15;3(3):CD011557. doi: 10.1002/14651858.CD011557.pub2.
4
Outcome of latent tuberculosis infection in solid organ transplant recipients over a 10-year period.
Transplantation. 2014 Sep 27;98(6):671-5. doi: 10.1097/TP.0000000000000133.
5
An interdisciplinary approach to the older transplant patient: strategies for improving clinical outcomes.
Curr Opin Organ Transplant. 2019 Aug;24(4):504-510. doi: 10.1097/MOT.0000000000000662.
6
Perceptions and Practices Regarding Frailty in Kidney Transplantation: Results of a National Survey.
Transplantation. 2020 Feb;104(2):349-356. doi: 10.1097/TP.0000000000002779.
7
Transplant centers that assess frailty as part of clinical practice have better outcomes.
BMC Geriatr. 2022 Jan 27;22(1):82. doi: 10.1186/s12877-022-02777-2.
8
9
Frailty and solid-organ transplant candidates: a scoping review.
BMC Geriatr. 2022 Nov 16;22(1):864. doi: 10.1186/s12877-022-03485-7.
10
Frailty Prevalence in Younger End-Stage Kidney Disease Patients Undergoing Dialysis and Transplantation.
Am J Nephrol. 2020;51(7):501-510. doi: 10.1159/000508576. Epub 2020 Jul 8.

本文引用的文献

1
Impact of pre-existing frailty on survival outcomes in solid-organ transplant candidates and recipients: A meta-analysis.
Ageing Res Rev. 2024 Aug;99:102364. doi: 10.1016/j.arr.2024.102364. Epub 2024 Jun 3.
2
Frailty in older adults: evidence for a phenotype.
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. doi: 10.1093/gerona/56.3.m146.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验