Kochetkov S N
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
Mol Biol (Mosk). 2024 Nov-Dec;58(6):851-861.
Antibiotic and, more broadly, antimicrobial resistance is a naturally occurring biological phenomenon and a major public health problem. Mass emergence of drug-resistant bacterial strains was first observed in the mid-20th century. Since then, cases of resistance have been reported worldwide, and multidrug resistance has been increasingly reported over the past two decades. Overuse of antibacterial agents and their release into the environment contribute to the development of bacterial resistance. Unfortunately, a search and design of new effective antibiotics are declining, while it is necessary to intensify such studies and to search for alternative methods to treat infectious diseases.
抗生素，更广泛地说，抗菌药物耐药性是一种自然发生的生物学现象，也是一个重大的公共卫生问题。耐药细菌菌株的大量出现最早在20世纪中叶被观察到。从那时起，全球范围内都报告了耐药病例，并且在过去二十年中多重耐药性的报告越来越多。抗菌剂的过度使用及其释放到环境中促成了细菌耐药性的发展。不幸的是，新型有效抗生素的研究与设计正在减少，而加强此类研究并寻找治疗传染病的替代方法是很有必要的。
