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凯泽评分在非肿块强化乳腺病变中的作用

Contrıbutıon of Kaıser score in non-mass enhanced breast lesions.

作者信息

Karabulut Ummuhan Ebru, Celik Yabul Fatma, Polat Yagmur Basak, Donmez Zeynep, Toprak Huseyin, Alkan Alpay, Yildiz Seyma

机构信息

Bezmialem Vakif University, Faculty of Medicine, Department of Radiology, Fatih, Istanbul, Turkey.

Bezmialem Vakif University, Faculty of Medicine, Department of Radiology, Fatih, Istanbul, Turkey.

出版信息

Eur J Radiol. 2025 Apr;185:112002. doi: 10.1016/j.ejrad.2025.112002. Epub 2025 Feb 14.

Abstract

OBJECTIVE

Our study aimed to investigate the effectiveness of Kaiser Score (KS) in diagnosing Non-mass enhanced (NME) lesions and its impact on the inter-reader agreement between experienced and inexperienced readers.

MATERIALS AND METHODS

A retrospective analysis was conducted on 189 NME lesions from 182 MRIs. Two readers (an experienced radiologist and a radiology resident) independently evaluated lesions using the KS, blinded to clinical and pathological data. The KS was modified (MKS) by adding 2 points for microcalcifications on mammography and subtracting 4 points for ADC values > 1.4 x 10^-3 mm/s. Interobserver agreement was assessed with the Intraclass Correlation Coefficient (ICC), and diagnostic performance was evaluated via ROC analysis, with sensitivity and specificity calculated at > 4 and > 5 cut-offs.

RESULTS

Interobserver agreement improved with MKS (ICC: 0.763) compared to KS (ICC: 0.667). For the experienced reader, both KS and MKS achieved high sensitivity (>94 %) at a cut-off of > 4. At > 5, specificity improved from 40.5 % to 58.7 % for KS and 39.1 % to 55.8 % for MKS without significantly affecting sensitivity. For the inexperienced reader, MKS improved sensitivity (96.8 %) and specificity (39 %) at > 4. At > 5, specificity increased to 55.8 %, with a non-significant decrease in sensitivity (86.2 %).

CONCLUSION

The Kaiser Score is a quick and systematic tool that enhances diagnostic accuracy and reduces biopsy rates, particularly benefiting inexperienced readers. While higher thresholds improve specificity for experienced readers, they may reduce sensitivity for inexperienced readers, potentially missing malignancies. As a complement to BI-RADS, the Kaiser Score helps standardize evaluations and bridge experience gaps in MRI interpretation.

摘要

目的

本研究旨在探讨凯泽评分(KS)在诊断非肿块强化(NME)病变中的有效性及其对经验丰富和经验不足的阅片者之间阅片一致性的影响。

材料与方法

对182例MRI检查中的189个NME病变进行回顾性分析。两名阅片者(一名经验丰富的放射科医生和一名放射科住院医师)在不知道临床和病理数据的情况下,使用KS对病变进行独立评估。通过在乳腺钼靶检查中对微钙化加2分以及对表观扩散系数(ADC)值>1.4×10^-3 mm/s减4分来对KS进行修改(MKS)。采用组内相关系数(ICC)评估观察者间的一致性,并通过ROC分析评估诊断性能,在>4和>5的截断值处计算敏感性和特异性。

结果

与KS(ICC:0.667)相比,MKS使观察者间的一致性得到改善(ICC:0.763)。对于经验丰富的阅片者,KS和MKS在截断值>4时均达到高敏感性(>94%)。在截断值>5时,KS的特异性从40.5%提高到58.7%,MKS的特异性从39.1%提高到55.8%,且敏感性未受到显著影响。对于经验不足的阅片者,MKS在截断值>4时提高了敏感性(96.8%)和特异性(39%)。在截断值>5时,特异性提高到55.8%,敏感性有不显著的下降(86.2%)。

结论

凯泽评分是一种快速且系统的工具,可提高诊断准确性并降低活检率,对经验不足的阅片者尤其有益。虽然较高的截断值可提高经验丰富的阅片者的特异性,但可能会降低经验不足的阅片者的敏感性,从而可能漏诊恶性肿瘤。作为乳腺影像报告和数据系统(BI-RADS)的补充,凯泽评分有助于规范评估并弥合MRI解读中的经验差距。

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