Paterson Samantha, Vallatos Antoine, Graff Camille, Holmes William M
Research and Innovation, University of Aberdeen, UK; Glasgow Experimental MRI Centre, School of Psychology and Neuroscience, University of Glasgow, UK.
Glasgow Experimental MRI Centre, School of Psychology and Neuroscience, University of Glasgow, UK.
Magn Reson Imaging. 2025 Jun;119:110361. doi: 10.1016/j.mri.2025.110361. Epub 2025 Feb 17.
mbASL relies on the use of a series of adiabatic radio-frequency pulses to label successive boli of blood water. As the sequence is a hybrid of pCASL and PASL, it requires an appropriate kinetic model to accurately describe the signal for quantification purposes.
Drawing on the Buxton standard kinetic model, we propose modifications to account for the multiple labeling pulses at variable delays. By varying the number of adiabatic pulses and the thickness of the inversion slab, we maximize SNR and demonstrate the hybrid nature of the sequence.
The mbASL kinetic model is used to produce mbASL cerebral blood flow maps, with average values for mice (110 ml/100 g/min) and rats (96 ml/100 g/min).
We have successfully quantified and validated the mbASL kinetic model and demonstrated that the resulting CBF values agree with the existing literature.
