Li Linna, Zhu Chuanmei, Yan Qianwen, Li Juejin, Chen Yang, Hu Xiaolin
Department of Nursing, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China.
Outpatient Department, West China Hospital, Sichuan University, Chengdu, China.
J Clin Nurs. 2025 Aug;34(8):3383-3405. doi: 10.1111/jocn.17700. Epub 2025 Feb 19.
Increases in cancer survivorship negatively impact patients and family caregivers, decreasing quality of life. Previous dyadic interventions involved them as a unit and focused on their outcomes, but inconsistent results existed in influencing quality of life.
To assess dyadic intervention effect on quality of life for cancer patients and family caregivers across different cancer types and intervention durations.
A systematic review and meta-analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Six databases were searched from establishment until 14 January 2024. Two authors independently performed the search process, literature screening, and data extraction. The ROB version 2 and GRADE were respectively used to check the methodology and evidence quality. The data were analysed via RStudio, and intervention effects were estimated with 95% CIs and SMDs. The statistical heterogeneity was explored through the I statistic, P values, and Egger's test, and differences in overall effects were deemed statistically significant, having a P value < 0.05. Subgroup analysis was also conducted.
13 RCTs with 1625 participants, published from 2005 to 2021, were included. The results demonstrated that dyadic interventions enhanced quality of life for both cancer patients and family caregivers. Subgroup analysis suggested that family-centred interventions for patients with specific cancer types, which lasted for a long period (> 6 weeks), enhanced quality of life for cancer patients and family caregivers. The evidence and methodology were of a moderate quality.
Nurses are important practitioners of culture-oriented dyadic interventions. Long-term (> 6 weeks) and family-centred dyadic interventions for patients with a specific cancer type can enhance cancer patients' and family caregivers' quality of life, along with digital intelligence approaches to promote mutual communication and strengthen family relationships, thereby optimising oncology clinical nursing and enhancing the quality of life, health, and welfare of the entire family.
Dyadic interventions emphasising the involvement of both cancer patients and family caregivers should be considered and tailored by professionals and oncology nurses to establish harmonious family relationships, improve family coping techniques and decision-making to enhance the whole family's quality of life and well-being according to their cultural contexts, and promote more efficient, targeted, and economical oncology care.
No Patient or Public Contribution because all the involved participants were from existing studies, and the design, conduction, analysis, and interpretation of the data were completed by the authors in this article.
International Prospective Register of Systematic Reviews: CRD42024519432; https://www.crd.york.ac.uk/PROSPERO/#recordDetails.
癌症幸存者人数的增加对患者及其家庭照顾者产生了负面影响，降低了生活质量。以往的二元干预将他们作为一个整体，关注他们的结果，但在影响生活质量方面存在不一致的结果。
评估二元干预对不同癌症类型和干预持续时间的癌症患者及其家庭照顾者生活质量的影响。
基于系统评价和Meta分析的首选报告项目（PRISMA）进行系统评价和Meta分析。
检索了6个数据库，检索时间从建库至2024年1月14日。两名作者独立进行检索、文献筛选和数据提取。分别使用ROB 2版和GRADE检查方法学和证据质量。通过RStudio对数据进行分析，采用95%置信区间和标准化均数差估计干预效果。通过I统计量、P值和Egger检验探讨统计异质性，总体效应差异具有统计学意义（P值<0.05）。还进行了亚组分析。
纳入了2005年至2021年发表的13项随机对照试验，共1625名参与者。结果表明，二元干预提高了癌症患者及其家庭照顾者的生活质量。亚组分析表明，针对特定癌症类型患者的长期（>6周）以家庭为中心的干预提高了癌症患者及其家庭照顾者的生活质量。证据和方法学质量中等。
护士是文化导向型二元干预的重要实施者。针对特定癌症类型患者的长期（>6周）以家庭为中心的二元干预，以及采用数字智能方法促进相互沟通和加强家庭关系，可以优化肿瘤临床护理，提高整个家庭的生活质量、健康水平和幸福感。
专业人员和肿瘤护士应考虑并定制强调癌症患者及其家庭照顾者共同参与的二元干预措施，以根据文化背景建立和谐的家庭关系，改善家庭应对技巧和决策，提高整个家庭的生活质量和幸福感，并促进更高效、有针对性和经济的肿瘤护理。
无患者或公众贡献，因为所有参与的参与者均来自现有研究，数据的设计、实施、分析和解释均由本文作者完成。
国际前瞻性系统评价注册库：CRD42024519432；https://www.crd.york.ac.uk/PROSPERO/#recordDetails。
