Keiser H R, Goldstein D S, Wade J L, Douglas F L, Averbuch S D
Hypertension. 1985 May-Jun;7(3 Pt 2):I18-24. doi: 10.1161/01.hyp.7.3_pt_2.i18.
Three patients with rapidly progressive, disseminated malignant pheochromocytoma were treated with a combination chemotherapeutic regimen consisting of cyclophosphamide, vincristine, and dacarbazine in repeated 21- to 28-day cycles. All three patients had a marked decrease in blood pressure and an improvement in performance status within the first few cycles of treatment. At a follow-up of 6 to 13 months all patients continue to receive chemotherapy with further regression of tumor in two and stable disease in one. Their blood pressure is normal with minimal or no antiadrenergic therapy. Therapy has been well tolerated; moderate reversible granulocytopenia, neurotoxicity, and one episode of pneumonitis have been the major toxicities encountered. Thus, combination chemotherapy appears to be effective for symptomatic malignant pheochromocytoma.
三名患有快速进展性、播散性恶性嗜铬细胞瘤的患者接受了由环磷酰胺、长春新碱和达卡巴嗪组成的联合化疗方案治疗，治疗周期为21至28天，重复进行。所有三名患者在治疗的前几个周期内血压均显著下降，身体状况得到改善。在6至13个月的随访中，所有患者继续接受化疗，两名患者肿瘤进一步消退，一名患者病情稳定。他们的血压正常，仅需极少或无需抗肾上腺素能治疗。治疗耐受性良好；主要的毒性反应包括中度可逆性粒细胞减少、神经毒性和一次肺炎发作。因此，联合化疗似乎对有症状的恶性嗜铬细胞瘤有效。
