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[嗜铬细胞瘤的治疗策略]

[Therapeutic strategy for pheochromocytoma].

作者信息

Iihara Masatoshi

机构信息

Dept. of Endocrine Surgery, Tokyo Women's Medical University, Shinjuka-ku, Tokyo, Japan.

出版信息

Gan To Kagaku Ryoho. 2009 Oct;36(10):1623-6.

Abstract

Pheochromocytoma is the most common type of neuroendocrine tumor arising from the adrenal gland. Pheochromocytoma has been termed a 10% tumor because roughly 10% of such tumors are malignant, multifocal, bilateral, and arise in extra-adrenal sites. During the last decade, laparoscopic adrenalectomy has been the standard method to remove pheochromocytomas. Adrenal-sparing laparoscopic surgery is a treatment of choice for bilateral pheochromocytomas. Cyclophosphamide, vincristine and dacarbazine combined chemotherapy and (131)I-MIBG therapy are required for the treatment of metastatic or unresectable malignant pheochromocytoma.

摘要

嗜铬细胞瘤是肾上腺最常见的神经内分泌肿瘤类型。嗜铬细胞瘤被称为“10%肿瘤”,因为大约10%的此类肿瘤是恶性、多灶性、双侧性的,并且发生在肾上腺外部位。在过去十年中,腹腔镜肾上腺切除术一直是切除嗜铬细胞瘤的标准方法。保留肾上腺的腹腔镜手术是双侧嗜铬细胞瘤的首选治疗方法。对于转移性或不可切除的恶性嗜铬细胞瘤,需要环磷酰胺、长春新碱和达卡巴嗪联合化疗以及(131)I-间碘苄胍治疗。

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