Ismail S I, Tawashi R, Ismail Z
Int Urol Nephrol. 1985;17(1):3-10. doi: 10.1007/BF02089396.
As a result of a continuing programme to understand better the uric acid stone treatment and prophylaxis, an investigation of the effect of pH and urine dilution on the surface charge of uric acid crystals was undertaken. A microelectrophoretic technique was employed to characterize the nature of the surface charge and the electrokinetics of uric acid crystals both in natural and synthetic urines under different conditions of pH and dilution. Both dilution and alkalization reduced the specific conductance of urine and increased the electrophoretic mobility (zeta potential) of uric acid crystals. The presence of cationic additives in diluted urine altered the zeta potential of uric acid crystals. Such findings suggest that proper control of the pH level and urine dilution as well as the surface charge at the solid-liquid interface represent an important factor in the uric acid stone prophylaxis.
为了更好地理解尿酸结石的治疗和预防，我们开展了一项持续的研究项目，对pH值和尿液稀释度对尿酸晶体表面电荷的影响进行了调查。我们采用微电泳技术来表征在不同pH值和稀释度条件下，天然尿液和合成尿液中尿酸晶体的表面电荷性质和电动现象。稀释和碱化都会降低尿液的电导率，并增加尿酸晶体的电泳迁移率（ζ电位）。稀释尿液中阳离子添加剂的存在会改变尿酸晶体的ζ电位。这些发现表明，适当控制pH值、尿液稀释度以及固液界面的表面电荷是预防尿酸结石的一个重要因素。
