Li Yishuo, Xing Yue, Liu Ning, Liu Bin, Wang Zhihui
Department of Cardiology, The Second Hospital of Jilin University, Changchun, China.
Front Pharmacol. 2025 Feb 5;16:1507282. doi: 10.3389/fphar.2025.1507282. eCollection 2025.
The gene locus is not only extensive but also intricate, and it could promote fibrosis in different organs or tissues, including cardiac fibrosis, liver fibrosis, kidney fibrosis, pulmonary fibrosis, as well as other organ fibrosis. Many disorders are associated with the process of fibrosis; moreover, fibrosis is a common symptom of chronic inflammatory diseases, characterized by the accumulation of excessive components in the extracellular matrix through different signaling pathways. The advanced stage of the fibrotic process leads to organ dysfunction and, ultimately, death. In this review, we first give an overview of the original structure and functions of SOX9. Second, we will discuss the role of SOX9 in fibrosis in various organs or tissues. Third, we describe and reveal the possibility of SOX9 as an antifibrotic treatment target. Finally, we will focus on the application of novel technologies for SOX9 and the subsequent investigation of fibrosis.
基因位点不仅广泛而且复杂，它可促进不同器官或组织的纤维化，包括心脏纤维化、肝纤维化、肾纤维化、肺纤维化以及其他器官纤维化。许多病症都与纤维化过程相关；此外，纤维化是慢性炎症性疾病的常见症状，其特征是通过不同信号通路在细胞外基质中积累过多成分。纤维化过程的晚期会导致器官功能障碍，并最终导致死亡。在本综述中，我们首先概述SOX9的原始结构和功能。其次，我们将讨论SOX9在各种器官或组织纤维化中的作用。第三，我们描述并揭示SOX9作为抗纤维化治疗靶点的可能性。最后，我们将重点关注SOX9新技术的应用以及随后对纤维化的研究。
