制霉菌素：β-环糊精与洗必泰：β-环糊精粘膜粘附水凝胶用于特定部位的口腔应用。
Nystatin:β-cyclodextrin and chlorhexidine:β-cyclodextrin mucoadhesive hydrogels for site-specific buccal applications.
作者信息
Garcia Amanda Aparecida Maia Neves, Aenishanslin Juliana, Sugio Carolina Yoshi Campos, da Silva Thais Letícia Moreira, Urban Vanessa Migliorini, Marinho Marina Tolentino, de Melo Carvalho Benjamim, Neppelenbroek Karin Hermana, Ferrari Priscileila Colerato
机构信息
Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo (USP), Bauru, Brazil.
Department of Pharmaceutical Sciences, State University of Ponta Grossa (UEPG), Ponta Grossa, Brazil.
出版信息
Ther Deliv. 2025 Apr;16(4):327-338. doi: 10.1080/20415990.2025.2467018. Epub 2025 Feb 20.
BACKGROUND
This study aimed to develop and analyze nystatin:β-cyclodextrin and chlorhexidine:β-cyclodextrin mucoadhesive hydrogels.
MATERIALS & METHODS: Hydrogels were characterized by and analyses, and antifungal activity against .
RESULTS
The hydrogel showed high adhesiveness and retention (83.37 ± 2.05%) to the porcine oral mucosa. The drug release from complexed nystatin and chlorhexidine hydrogels was 1.5 (95 µg/cm) and 4.0 times higher (800 µg/cm) than non-complexed drugs. Rheological studies indicated the prevalence of elastic behavior of the formulations. permeation using porcine mucosa showed retention on the oral mucosa. Hydrogels with nystatin and chlorhexidine inclusion complex showed inhibition percentages of 88.87% and 91.57%, respectively, and median inhibition zones of 8 mm.
CONCLUSION
Mucoadhesive hydrogels with inclusion complex are promising for oral lesions with greater retention at the treatment site.
背景
本研究旨在研发并分析制霉菌素：β-环糊精和氯己定：β-环糊精黏膜黏附水凝胶。
材料与方法
通过[具体分析方法1]和[具体分析方法2]分析对水凝胶进行表征，并检测其对[具体真菌名称]的抗真菌活性。
结果
该水凝胶对猪口腔黏膜表现出高黏附性和滞留性（83.37±2.05%）。与制霉菌素和氯己定复合的水凝胶的药物释放量分别比未复合药物高1.5倍（95μg/cm）和4.0倍（800μg/cm）。流变学研究表明制剂以弹性行为为主。使用猪黏膜进行的渗透实验显示在口腔黏膜上有滞留。含制霉菌素和氯己定包合物的水凝胶的抑制率分别为88.87%和91.57%，中位抑菌圈为8mm。
结论
含包合物的黏膜黏附水凝胶对于口腔病变具有前景，在治疗部位有更高的滞留性。
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