Poffenbarger E M, Hardy R M
J Am Vet Med Assoc. 1985 May 1;186(9):978-80.
The anticonvulsant drug, primidone, was believed to be responsible for the development of hepatic cirrhosis in a 9-year-old German Shepherd Dog with idiopathic epilepsy. Marked increases in serum alanine aminotransferase, serum alkaline phosphatase, total bilirubin, and sulfobromophthalein retention, as well as decreases in albumin and BUN supported the diagnosis of hepatic failure. Biochemical abnormalities improved after primidone was discontinued. Previous reports indicated a poor prognosis for anticonvulsant-induced hepatic failure; however, this dog has remained stable for over a year after diagnosis and proper therapy.
抗惊厥药物扑米酮被认为是导致一只患有特发性癫痫的9岁德国牧羊犬发生肝硬化的原因。血清丙氨酸转氨酶、血清碱性磷酸酶、总胆红素和磺溴酞钠潴留显著升高，以及白蛋白和血尿素氮降低，支持了肝功能衰竭的诊断。停用扑米酮后生化异常情况有所改善。先前的报告表明抗惊厥药引起的肝功能衰竭预后不良；然而，这只狗在诊断和适当治疗后已经稳定了一年多。
