Wei Tzu-Jung, Hsu Hsin-An, Hsiung Ping-Yan, Chen Ping-Ju, Lee Chen-Tse, Wu Chun-Yu
Department of Anesthesiology, National Taiwan University Hospital, Taipei City, Taiwan.
Department of Anesthesiology, National Taiwan University Hospital Yunlin Branch, Yunlin County, Taiwan.
J Formos Med Assoc. 2025 Feb 19. doi: 10.1016/j.jfma.2025.02.021.
Thoracotomy is a highly painful surgical procedure, with thoracic epidural analgesia (TEA) serving as the gold standard for postoperative pain management. However, TEA can induce significant hypotension, especially when combined with general anesthesia. The ultrasound-guided erector spinae plane block (ESPB) has emerged as a complementary technique for enhancing analgesia while minimizing side effects. This study compares the analgesic efficacy and intraoperative hemodynamic outcomes of preoperative TEA with and without ESPB in patients undergoing thoracotomy.
This retrospective cohort study was conducted at a tertiary university hospital, including patients who underwent thoracotomy for tumor resection between March 2017 and March 2023. Patients receiving ESPB prior to TEA were compared with those receiving TEA alone. Postoperative pain intensity and intraoperative hemodynamic stability were assessed. The primary outcome was postoperative pain scores, while secondary outcomes included intraoperative mean arterial pressure and postoperative outcomes such as length of hospital stay.
A total of 64 patients were enrolled in the study, including 43 who received TEA alone and 21 who received a combination of TEA and ESPB. After propensity score matching, 21 patients were matched 1:1 in each group for comparative analysis. Patients who received ESPB in addition to TEA had significantly lower pain scores at 1 h and 24 h postoperatively (p < 0.001). Additionally, they demonstrated higher intraoperative mean arterial pressures (p = 0.036) compared to the TEA-only group. However, there were no significant differences in postoperative outcomes.
The combination of preoperative ESPB and TEA provides superior early postoperative pain control and enhances intraoperative hemodynamic stability in thoracotomy patients compared to TEA alone.
开胸手术是一种极具疼痛性的外科手术,胸段硬膜外镇痛(TEA)是术后疼痛管理的金标准。然而,TEA可导致显著的低血压,尤其是与全身麻醉联合使用时。超声引导下竖脊肌平面阻滞(ESPB)已成为一种辅助技术,可增强镇痛效果同时将副作用降至最低。本研究比较了术前TEA联合与不联合ESPB在开胸手术患者中的镇痛效果及术中血流动力学结果。
本回顾性队列研究在一所三级大学医院进行,纳入2017年3月至2023年3月期间因肿瘤切除接受开胸手术的患者。将TEA前接受ESPB的患者与仅接受TEA的患者进行比较。评估术后疼痛强度和术中血流动力学稳定性。主要结局为术后疼痛评分,次要结局包括术中平均动脉压及术后住院时间等结局。
本研究共纳入64例患者,其中43例仅接受TEA治疗,21例接受TEA与ESPB联合治疗。经过倾向评分匹配后,每组各有21例患者进行1:1匹配以进行比较分析。除TEA外还接受ESPB的患者术后1小时和24小时的疼痛评分显著更低(p < 0.001)。此外,与仅接受TEA的组相比,他们术中平均动脉压更高(p = 0.036)。然而,术后结局无显著差异。
与单纯TEA相比,术前ESPB与TEA联合应用可在开胸手术患者中提供更优的术后早期疼痛控制,并增强术中血流动力学稳定性。