Colbert Sarah M C, Lepow Lauren, Fennessy Brian, Iwata Nakao, Ikeda Masashi, Saito Takeo, Terao Chikashi, Preuss Michael, Pathak Jyotishman, Mann J John, Coon Hilary, Mullins Niamh
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Transl Psychiatry. 2025 Feb 20;15(1):63. doi: 10.1038/s41398-025-03287-6.
Suicidal ideation (SI) and behavior (SB) are major public health concerns, but risk factors for their development and progression are poorly understood. We used ICD codes and a natural language processing algorithm to identify individuals in a hospital biobank with SI-only, SB, and controls without either. We compared the profiles of SB and SI-only patients to controls, and each other, using phenome-wide association studies (PheWAS) and polygenic risk scores (PRS). PheWAS identified many risk factors for SB and SI-only, plus specific psychiatric disorders which may be involved in progression from SI-only to SB. PRS for suicide attempt were only associated with SB, and even after accounting for psychiatric disorder PRS. SI PRS were only associated with SI-only, although not after accounting for psychiatric disorder PRS. These findings advance understanding of distinct genetic and clinical risk factors for SB and SI-only, which will aid in early detection and intervention efforts.
自杀意念（SI）和行为（SB）是主要的公共卫生问题，但对其发生和发展的风险因素了解甚少。我们使用国际疾病分类代码和自然语言处理算法，在医院生物样本库中识别出仅有自杀意念、有自杀行为以及既无自杀意念也无自杀行为的对照个体。我们使用全表型组关联研究（PheWAS）和多基因风险评分（PRS），将有自杀行为和仅有自杀意念的患者的特征与对照组进行比较，并相互比较。PheWAS确定了许多有自杀行为和仅有自杀意念的风险因素，以及可能参与从仅有自杀意念发展到自杀行为过程的特定精神障碍。自杀未遂的PRS仅与自杀行为相关，即使在考虑精神障碍PRS之后也是如此。自杀意念的PRS仅与仅有自杀意念相关，尽管在考虑精神障碍PRS之后并非如此。这些发现增进了对自杀行为和仅有自杀意念的不同遗传和临床风险因素的理解，这将有助于早期发现和干预工作。
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