The effect of perioperative probiotics and synbiotics on postoperative infections in patients undergoing major liver surgery: a meta-analysis of randomized controlled trials.

OBJECTIVE

To evaluate the effect of perioperative probiotics or synbiotics on the incidence of postoperative infections following major liver surgery.

DESIGN

Meta-analysis.

DATA SOURCES

PubMed, Embase, Scopus, and the Cochrane Library for relevant English-language studies published up to February 21st, 2024.

ELIGIBILITY CRITERIA

Randomized controlled trials evaluating perioperative probiotics or synbiotics for preventing postoperative infections in patients undergoing major liver surgery.

DATA EXTRACTION AND SYNTHESIS

Outcomes included postoperative infection incidence, antibiotic therapy duration, length of stay in intensive care unit (ICU) and hospital. A random-effect model was adopted for the meta-analysis. The quality of included studies was evaluated using the Cochrane risk of bias tool.

RESULTS

Ten studies involving 588 patients were included. Pooled analyses revealed that perioperative probiotics or synbiotics significantly reduced postoperative infection incidence (RR 0.36, 95% CI [0.24-0.54],  < 0.0001, I = 6%) and antibiotic therapy duration (MD -2.82, 95% CI [-3.13 to -2.51],  < 0.001, I = 0%). No significant differences were observed in length of stay in ICU (MD -0.25, 95% CI [-0.84-0.34],  = 0.41, I = 64%) or length of stay in hospital (MD -1.25, 95% CI [-2.74-0.25],  = 0.10, I = 56%).

CONCLUSIONS

This meta-analysis suggests that perioperative administration of probiotics or synbiotics may reduce the incidence of postoperative infections and duration of antibiotic therapy. Their use as adjunctive therapy during the perioperative period could be considered for patients undergoing major liver surgery.