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尾骨痛的管理:近期临床试验系统评价的要点

Management of coccygodynia: talking points from a systematic review of recent clinical trials.

作者信息

Mazzoleni Manuel Giovanni, Maffulli Nicola, Bardazzi Tommaso, Memminger Michael, Bertini Francesca Alzira, Migliorini Filippo

机构信息

Department of Orthopaedic and Trauma Surgery, Academic Hospital of Bolzano (SABES-ASDAA), Bolzano, Italy.

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, Roma, Italy.

出版信息

Ann Jt. 2025 Jan 21;10:9. doi: 10.21037/aoj-24-40. eCollection 2025.

Abstract

BACKGROUND

Coccygodynia, characterised by localised pain in the coccyx and surrounding tissues, presents challenges in diagnosis and management given its low prevalence and varied aetiology. Traumatic injury, particularly backward falls, is commonly implicated, while non-traumatic causes include degenerative joint disease, overloading stress forces from obesity and morphological variations of the coccyx. Diagnostic evaluation involves medical history, physical examination, and radiographic imaging. While conservative management is often successful, refractory cases necessitate intervention. However, optimal treatment strategies still need to be clarified. The present systematic review discusses the clinical evidence on the management of coccygodynia.

METHODS

In December 2024, a systematic review followed PRISMA guidelines, accessing PubMed, Web of Science, and Embase databases. Eligible studies included solely clinical trials investigating coccygodynia management. The risk of bias was assessed using Cochrane risk of bias assessment tool (RoB2) for randomized controlled trials (RCTs) and the Risk of Bias in nonrandomized Studies of Interventions (ROBINS-I) for non-RCTs. Data extraction and statistical analyses followed the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions.

RESULTS

Of 407 identified articles, 16 met inclusion criteria, comprising 858 patients, primarily women. Risk of bias assessment revealed varying methodological quality among included studies. Conservative treatments, including physiotherapy and shockwave therapy, showed promise in pain management. Interventional therapies, such as corticosteroid injections and ganglion-impair blockade, demonstrated efficacy in refractory cases. Surgical interventions, particularly coccygectomy, yielded moderate success rates but were associated with notable risks.

CONCLUSIONS

A multidisciplinary approach is advocated for managing coccygodynia, with conservative measures as initial strategies. Physical therapy-based interventions and interventional treatments, such as corticosteroid injections and ganglion impair blockade, offer viable options for refractory cases. Surgical intervention should be considered judiciously, weighing risks and benefits based on patient-specific factors and treatment response. Further research is needed to establish standardized guidelines for coccygodynia management based on high-quality evidence.

摘要

背景

尾骨痛表现为尾骨及其周围组织的局部疼痛,鉴于其低患病率和多样的病因,在诊断和管理方面存在挑战。创伤性损伤,尤其是向后跌倒,通常与之相关,而非创伤性原因包括退行性关节疾病、肥胖引起的过载应力以及尾骨的形态变异。诊断评估包括病史、体格检查和影像学检查。虽然保守治疗通常很成功,但难治性病例需要干预。然而,最佳治疗策略仍有待明确。本系统评价讨论了尾骨痛管理的临床证据。

方法

2024年12月,按照PRISMA指南进行系统评价,检索了PubMed、科学网和Embase数据库。符合条件的研究仅包括调查尾骨痛管理的临床试验。使用Cochrane偏倚风险评估工具(RoB2)对随机对照试验(RCT)进行偏倚风险评估,并使用非随机干预研究中的偏倚风险(ROBINS-I)对非RCT进行评估。数据提取和统计分析遵循Cochrane干预系统评价手册的建议。

结果

在407篇已识别的文章中,16篇符合纳入标准,共858例患者,主要为女性。偏倚风险评估显示,纳入研究的方法学质量各不相同。保守治疗,包括物理治疗和冲击波治疗,在疼痛管理方面显示出前景。介入治疗,如皮质类固醇注射和神经节损伤阻滞,在难治性病例中显示出疗效。手术干预,尤其是尾骨切除术,成功率中等,但存在显著风险。

结论

提倡采用多学科方法管理尾骨痛,以保守措施作为初始策略。基于物理治疗的干预措施以及介入治疗,如皮质类固醇注射和神经节损伤阻滞,为难治性病例提供了可行的选择。应谨慎考虑手术干预,根据患者的具体因素和治疗反应权衡风险和益处。需要进一步研究以基于高质量证据建立尾骨痛管理的标准化指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3fb/11836747/b7bd83b96c93/aoj-10-9-f1.jpg

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