Das Gupta V, Stewart K R
J Clin Hosp Pharm. 1985 Mar;10(1):67-72. doi: 10.1111/j.1365-2710.1985.tb00717.x.
The chemical stabilities of metronidazole (in water) and ten antibiotics (ampicillin, carbenicillin, cefamandole, cefazolin, cefoxitin, moxalactam, nafcillin, penicillin G, piperacillin, and ticarcillin) in 5% dextrose injection (except ampicillin which was in 0.9% sodium chloride) with magnesium sulphate were studied at 25 degrees C. The clarity of the solutions did not change in 20 h. The pH values of metronidazole, nafcillin and penicillin G solutions containing magnesium sulphate were lower (at 0 and 20 h) by up to 1.2 units as compared with solutions without magnesium sulphate. The decomposition of nafcillin and penicillin G solutions was hastened significantly by magnesium sulphate due to effect on the pH values of the solutions.
在25℃下，研究了甲硝唑（在水中）和十种抗生素（氨苄西林、羧苄西林、头孢孟多、头孢唑林、头孢西丁、莫西沙星、萘夫西林、青霉素G、哌拉西林和替卡西林）在含硫酸镁的5%葡萄糖注射液（氨苄西林在0.9%氯化钠中）中的化学稳定性。溶液的澄清度在20小时内未发生变化。与不含硫酸镁的溶液相比，含硫酸镁的甲硝唑、萘夫西林和青霉素G溶液的pH值（在0小时和20小时时）降低了多达1.2个单位。由于对溶液pH值的影响，硫酸镁显著加速了萘夫西林和青霉素G溶液的分解。
