Maruyama Naoko, Uwamino Yoshifumi, Imai Yoko, Hirano Toshiyuki, Aoki Wataru, Minematsu Naoto
Department of Medicine, Hino Municipal Hospital, 4-3-1 Tamadaira, Hino-shi, Tokyo 191-0062, Japan.
Department of Laboratory Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Diagn Microbiol Infect Dis. 2025 May;112(1):116747. doi: 10.1016/j.diagmicrobio.2025.116747. Epub 2025 Feb 14.
Infection caused by Schaalia cardiffensis, formerly Actinomyces cardiffensis, is uncommon, and its clinical characteristics remain largely unknown. This report presents a case of S. cardiffensis infection causing critical illness in an elderly patient, along with a literature review. An 82-year-old Japanese man presented with septicemia caused by gram-positive rod-shaped bacteria, as well as pulmonary involvement representing septic embolisms, and disseminated intravascular coagulation. S. cardiffensis was identified in the anaerobic blood culture samples through 16S rRNA sequencing and database analysis. The patient recovered from the critical illness through extended antimicrobial treatment, primarily penicillin, along with supportive care. To the best of our knowledge, only three cases of S. cardiffensis infection have been reported in the literature. Two of these cases, along with the present one, exhibited disseminated infections in the lungs, liver, or brain. This organism may be highly virulent and prone to disseminated infections, warranting further investigation in future studies.
以前被称为卡迪夫放线菌的卡迪夫沙氏菌引起的感染并不常见，其临床特征在很大程度上仍不为人知。本报告介绍了一例卡迪夫沙氏菌感染导致老年患者危重病的病例，并进行了文献综述。一名82岁的日本男性出现由革兰氏阳性杆状细菌引起的败血症，以及表现为脓毒性栓塞的肺部受累和弥散性血管内凝血。通过16S rRNA测序和数据库分析，在厌氧血培养样本中鉴定出卡迪夫沙氏菌。患者通过延长抗菌治疗（主要是青霉素）以及支持治疗从危重病中康复。据我们所知，文献中仅报道了三例卡迪夫沙氏菌感染病例。其中两例与本病例一起，表现出肺部、肝脏或脑部的播散性感染。这种微生物可能具有高度毒性，易于发生播散性感染，值得在未来研究中进一步调查。
