美国成年人月经初潮和绝经时间与表观遗传衰老：1999 - 2002年美国国家健康和营养检查调查结果

Timing of menarche and menopause and epigenetic aging among U.S. adults: results from the National Health and Nutrition Examination Survey 1999-2002.

作者信息

Daredia Saher, Khodasevich Dennis, Gladish Nicole, Shen Hanyang, Nwanaji-Enwerem Jamaji C, Bozack Anne K, Needham Belinda L, Rehkopf David H, Deardorff Julianna, Cardenas Andres

机构信息

Division of Epidemiology, School of Public Health, University of California, Berkeley, USA.

Department of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, 94305, USA.

出版信息

Clin Epigenetics. 2025 Feb 21;17(1):31. doi: 10.1186/s13148-025-01827-x.

DOI:10.1186/s13148-025-01827-x

PMID:39984995

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11844159/

Abstract

Reproductive aging, including timing of menarche and menopause, influences long-term morbidity and mortality in women, yet underlying biological mechanisms remain poorly understood. Using DNA methylation-based biomarkers, we assessed associations of age at menarche (N = 1,033) and menopause (N = 658) with epigenetic aging in a nationally representative sample of women ≥ 50 years. Later age at menopause was associated with lower GrimAge epigenetic age deviation ( = - 0.10 years, 95% CI: - 0.19, - 0.02). No associations were observed for menarche timing. This suggests a connection between earlier menopause and biological aging, with potential clinical implications for identifying those at high risk for age-related disease.

摘要

生殖衰老，包括初潮和绝经时间，会影响女性的长期发病率和死亡率，但其潜在的生物学机制仍知之甚少。我们使用基于DNA甲基化的生物标志物，在一个全国代表性的50岁及以上女性样本中，评估了初潮年龄（N = 1,033）和绝经年龄（N = 658）与表观遗传衰老之间的关联。绝经年龄较晚与较低的GrimAge表观遗传年龄偏差相关（β = -0.10岁，95%CI：-0.19，-0.02）。未观察到初潮时间与表观遗传衰老之间的关联。这表明绝经较早与生物衰老之间存在联系，对识别与年龄相关疾病的高危人群具有潜在的临床意义。