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A novel BaEVRless-LV packaging system for the production of lentiviral vectors for clinical-grade CAR-NK cell manufacturing.

作者信息

Zhang Yinyin, Zhang Minghuan, Li Mengyuan, Zong Lihong, Ye Qian, Lei Wen, Deng Wenhai, Qian Wenbin

机构信息

Department of Hematology, the Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310009, China.

Hangzhou RongGu Biotechnology Limited Company, Hangzhou 310056, China.

出版信息

Cancer Biol Med. 2025 Feb 21;22(2):137-43. doi: 10.20892/j.issn.2095-3941.2024.0551.

DOI:10.20892/j.issn.2095-3941.2024.0551
PMID:39985136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11899593/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8c/11899593/ce49149cf353/cbm-22-137-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8c/11899593/c8d885262ebb/cbm-22-137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8c/11899593/ce49149cf353/cbm-22-137-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8c/11899593/c8d885262ebb/cbm-22-137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb8c/11899593/ce49149cf353/cbm-22-137-g002.jpg

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本文引用的文献

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CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells.CRISPR/Cas9 编辑 NKG2A 提高了原代 CD33 导向嵌合抗原受体自然杀伤细胞的疗效。
Nat Commun. 2024 Sep 30;15(1):8439. doi: 10.1038/s41467-024-52388-1.
2
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Clin Transl Immunology. 2024 May 2;13(5):e1507. doi: 10.1002/cti2.1507. eCollection 2024.
3
Protocol for a high titer of BaEV-Rless pseudotyped lentiviral vector: Focus on syncytium formation and detachment.
高滴度无BaEV-R假型慢病毒载体的方案：关注合胞体形成和脱离。
J Virol Methods. 2023 Apr;314:114689. doi: 10.1016/j.jviromet.2023.114689. Epub 2023 Feb 3.
4
Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy.嵌合抗原受体自然杀伤 (CAR-NK) 细胞设计与工程在癌症治疗中的应用。
J Hematol Oncol. 2021 May 1;14(1):73. doi: 10.1186/s13045-021-01083-5.
5
Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector.用绢毛猴包膜假型慢病毒载体高效且稳健地转导 NK 细胞。
Front Immunol. 2019 Dec 16;10:2873. doi: 10.3389/fimmu.2019.02873. eCollection 2019.
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Cytoplasmic R-peptide of murine leukemia virus envelope protein negatively regulates its interaction with the cell surface receptor.鼠白血病病毒包膜蛋白的细胞质 R 肽负调控其与细胞表面受体的相互作用。
Virology. 2019 Jun;532:82-87. doi: 10.1016/j.virol.2019.04.005. Epub 2019 Apr 23.
7
Clinical use of lentiviral vectors.慢病毒载体的临床应用。
Leukemia. 2018 Jul;32(7):1529-1541. doi: 10.1038/s41375-018-0106-0. Epub 2018 Mar 22.
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BMC Res Notes. 2016 Jun 16;9:312. doi: 10.1186/s13104-016-2118-z.
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