CuO@TiC Integrated Photothermal Nanofibers with Antibacterial, Anti-Inflammatory, and Hemostatic Properties for Promoting Infected Diabetic Wound Healing.

Infected diabetic wounds represent a significant challenge in clinical care due to persistent inflammation and impaired healing. To address these issues, the development of novel wound dressings with both antibacterial and reactive oxygen species (ROS) scavenging properties is essential. Herein, we prepare a novel wound dressing composed of CuO nanoparticles decorated on TiC MXene (CuO@TiC) and integrate it into a poly(vinyl alcohol) (PVA) matrix to form electrospun nanofibers (CuO@TiC@PVA). CuO@TiC exhibits remarkable photothermal conversion efficiency and effective ROS scavenging properties. In vitro experiments demonstrated that CuO@TiC effectively kills bacteria upon near-infrared (NIR) irradiation, which can be attributed to the photothermal therapy (PTT) effect of TiC. At the same time, the ROS scavenging abilities of both TiC and CuO endow CuO@TiC with significant in vitro anti-inflammatory effects. As a promising wound dressing, in vivo studies validated the high efficacy of CuO@TiC@PVA in promoting hemostasis, exerting antibacterial activity, reducing inflammation, and accelerating the healing process of diabetic wounds. This innovative approach provides a comprehensive solution to the multifaceted challenges of diabetic wound healing and paves the way for improved clinical outcomes.