Luo Hang, Ma Xiaoxiao, Yuan Jingjing, Feng Yongqiang, Kong Lingxue, Shi Rui, Chen Yu
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
ACS Appl Mater Interfaces. 2025 May 7;17(18):26178-26190. doi: 10.1021/acsami.4c20769. Epub 2025 Apr 28.
In the field of wound exudate management, Janus dressings with unidirectional fluid transport capabilities have garnered extensive attention. However, the hydrophilic layer tends to be saturated during application, which often leads to significant declines in the drainage efficiency. To address this issue, this study constructed a Janus dressing with a hydrophilic-hydrophobic wettability gradient that could continuously evaporate the fluid in the hydrophilic layer. The hydrophilic nanofibers of poly(vinyl alcohol)-MXene (PVA-MXene) were deposited onto a hydrophobic nanofiber layer of polyurethane-MXene (PU-MXene) by sequential electrospinning to form a Janus dressing with asymmetric wettability. The dressing can enable unidirectional transport of exudate from the wound bed to the hydrophilic layer to effectively prevent the rewetting of the wound by the expelled biological fluid. The incorporation of MXene endows the dressing with photothermal responsiveness, allowing it to continuously expel exudate at a stable evaporation rate and maintain a moisture-unsaturated state. In addition, the photothermal effect imparts antibacterial activity to the dressing to prevent wound infections. In the application study using a rat wound infection model under NIR irradiation, the dressing demonstrated anti-inflammatory effects, promoted collagen deposition and angiogenesis, and thus significantly accelerated the wound healing process. Our study offered an innovative approach to the development of Janus structure dressings and provided an effective solution for wound exudate management.
在伤口渗出液管理领域，具有单向流体传输能力的双面敷料已引起广泛关注。然而，亲水性层在应用过程中容易饱和，这往往导致引流效率显著下降。为了解决这个问题，本研究构建了一种具有亲水-疏水润湿性梯度的双面敷料，该敷料能够持续蒸发亲水性层中的液体。通过连续静电纺丝将聚乙烯醇-碳化钛（PVA-MXene）的亲水性纳米纤维沉积在聚氨酯-碳化钛（PU-MXene）的疏水性纳米纤维层上，形成具有不对称润湿性的双面敷料。该敷料能够使渗出液从伤口床单向传输至亲水性层，有效防止排出的生物流体使伤口再次湿润。碳化钛的加入赋予了敷料光热响应性，使其能够以稳定的蒸发速率持续排出渗出液并保持水分不饱和状态。此外，光热效应赋予了敷料抗菌活性，可防止伤口感染。在近红外辐射下使用大鼠伤口感染模型的应用研究中，该敷料表现出抗炎作用，促进了胶原蛋白沉积和血管生成，从而显著加速了伤口愈合过程。我们的研究为双面结构敷料的开发提供了一种创新方法，并为伤口渗出液管理提供了有效解决方案。
